Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China
The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum efflux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β-naphthylamide (PAβN), on the contribution of m...
| Published in: | Journal of Integrative Agriculture |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2016-04-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095311915610310 |
| _version_ | 1848769589381431296 |
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| author | Ya-fei LI Hong-xia JIANG Rong XIANG Na SUN Ya-nan ZHANG Li-qing ZHAO Peng GU Li-qiao WANG Zhen-ling ZENG |
| author_facet | Ya-fei LI Hong-xia JIANG Rong XIANG Na SUN Ya-nan ZHANG Li-qing ZHAO Peng GU Li-qiao WANG Zhen-ling ZENG |
| author_sort | Ya-fei LI |
| collection | DOAJ |
| container_title | Journal of Integrative Agriculture |
| description | The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum efflux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β-naphthylamide (PAβN), on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftriaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestifer isolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates. |
| format | Article |
| id | doaj-art-28ea63f478fc4c4d9fa793b668b4ebd5 |
| institution | Directory of Open Access Journals |
| issn | 2095-3119 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| spelling | doaj-art-28ea63f478fc4c4d9fa793b668b4ebd52025-10-02T04:41:05ZengKeAi Communications Co., Ltd.Journal of Integrative Agriculture2095-31192016-04-0115492993310.1016/S2095-3119(15)61031-0Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from ChinaYa-fei LI0Hong-xia JIANG1Rong XIANG2Na SUN3Ya-nan ZHANG4Li-qing ZHAO5Peng GU6Li-qiao WANG7Zhen-ling ZENG8Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China; LI Ya-fei, Mobile: +86-13422293073Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.ChinaInstitute of Animal Healthy, Guangdong Academy of Agricultural Sciences/Guangdong Open Laboratory of Veterinary Public Health, Guangzhou 510640, P.R.ChinaInstitute of Special Animal and Plant Sciences, Chinese Academic of Agricultural Sciences, Changchun 130112, P.R.ChinaLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.ChinaLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.ChinaLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.ChinaLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.ChinaLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China; Correspondence ZENG Zhen-ling, Tel: +86-20-85281204, Fax: +86-20-85284896The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum efflux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β-naphthylamide (PAβN), on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftriaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestifer isolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.http://www.sciencedirect.com/science/article/pii/S2095311915610310Riemerella anatipestiferresistanceeffluxCCCPPAβN |
| spellingShingle | Ya-fei LI Hong-xia JIANG Rong XIANG Na SUN Ya-nan ZHANG Li-qing ZHAO Peng GU Li-qiao WANG Zhen-ling ZENG Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China Riemerella anatipestifer resistance efflux CCCP PAβN |
| title | Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China |
| title_full | Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China |
| title_fullStr | Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China |
| title_full_unstemmed | Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China |
| title_short | Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China |
| title_sort | effects of two efflux pump inhibitors on the drug susceptibility of riemerella anatipestifer isolates from china |
| topic | Riemerella anatipestifer resistance efflux CCCP PAβN |
| url | http://www.sciencedirect.com/science/article/pii/S2095311915610310 |
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