P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation
Localisation of mast cells (MCs) at the abluminal side of blood vessels in the brain favours their interaction with glial cells, neurons, and endothelial cells, resulting in the activation of these cells and the release of pro-inflammatory mediators. In turn, stimulation of glial cells, such as micr...
| Published in: | Cells |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2282 |
| _version_ | 1850350342889275392 |
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| author | Barbora Salcman Karen Affleck Silvia Bulfone-Paus |
| author_facet | Barbora Salcman Karen Affleck Silvia Bulfone-Paus |
| author_sort | Barbora Salcman |
| collection | DOAJ |
| container_title | Cells |
| description | Localisation of mast cells (MCs) at the abluminal side of blood vessels in the brain favours their interaction with glial cells, neurons, and endothelial cells, resulting in the activation of these cells and the release of pro-inflammatory mediators. In turn, stimulation of glial cells, such as microglia, astrocytes, and oligodendrocytes may result in the modulation of MC activities. MCs, microglia, astrocytes, and oligodendrocytes all express P2X receptors (P2XRs) family members that are selectively engaged by ATP. As increased concentrations of extracellular adenosine 5′-triphosphate (ATP) are present in the brain in neuropathological conditions, P2XR activation in MCs and glial cells contributes to the control of their communication and amplification of the inflammatory response. In this review we discuss P2XR-mediated MC activation, its bi-directional effect on microglia, astrocytes and oligodendrocytes and role in neuroinflammation. |
| format | Article |
| id | doaj-art-28edd23a82fc4b8db07e99cf5abc7ddd |
| institution | Directory of Open Access Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-28edd23a82fc4b8db07e99cf5abc7ddd2025-08-19T23:10:06ZengMDPI AGCells2073-44092021-09-01109228210.3390/cells10092282P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in NeuroinflammationBarbora Salcman0Karen Affleck1Silvia Bulfone-Paus2Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UKGlaxoSmithKline, Immunology Research Unit, Stevenage SG1 2NY, UKLydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UKLocalisation of mast cells (MCs) at the abluminal side of blood vessels in the brain favours their interaction with glial cells, neurons, and endothelial cells, resulting in the activation of these cells and the release of pro-inflammatory mediators. In turn, stimulation of glial cells, such as microglia, astrocytes, and oligodendrocytes may result in the modulation of MC activities. MCs, microglia, astrocytes, and oligodendrocytes all express P2X receptors (P2XRs) family members that are selectively engaged by ATP. As increased concentrations of extracellular adenosine 5′-triphosphate (ATP) are present in the brain in neuropathological conditions, P2XR activation in MCs and glial cells contributes to the control of their communication and amplification of the inflammatory response. In this review we discuss P2XR-mediated MC activation, its bi-directional effect on microglia, astrocytes and oligodendrocytes and role in neuroinflammation.https://www.mdpi.com/2073-4409/10/9/2282mast cellsmicrogliaastrocytesoligodendrocytesP2X receptors |
| spellingShingle | Barbora Salcman Karen Affleck Silvia Bulfone-Paus P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation mast cells microglia astrocytes oligodendrocytes P2X receptors |
| title | P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation |
| title_full | P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation |
| title_fullStr | P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation |
| title_full_unstemmed | P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation |
| title_short | P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation |
| title_sort | p2x receptor dependent modulation of mast cell and glial cell activities in neuroinflammation |
| topic | mast cells microglia astrocytes oligodendrocytes P2X receptors |
| url | https://www.mdpi.com/2073-4409/10/9/2282 |
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