A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine

Abstract Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal c...

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Bibliographic Details
Published in:Dermatology and Therapy
Main Authors: Xu-Cheng Shen, Xiang-Nong Dai, Zhi-Min Xie, Ping Li, Sha Lu, Jia-Hao Li, Yi Zhang, Xing-Dong Ye
Format: Article
Language:English
Published: Adis, Springer Healthcare 2020-02-01
Subjects:
Chromoblastomycosis
Fonsecaea pedrosoi
Fungal gene sequencing
In vitro antifungal susceptibility
Terbinafine
Online Access:https://doi.org/10.1007/s13555-020-00358-y
Description
Summary:Abstract Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal culture and gene sequencing. This patient was successfully treated with a regimen of oral itraconazole (ITZ) and terbinafine lasting 7 months. Through in vitro drug sensitivity tests, minimum inhibitory concentrations of amphotericin, ITZ, and terbinafine were 1 μg/ml, 0.25 μg/ml, and 1 μg/ml, respectively. In this case, terbinafine was found to be more effective than ITZ.
ISSN:2193-8210
2190-9172

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