Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation
IntroductionThe migrasome is a newly discovered organelle that resembles extracellular vesicles in structure. However, the function of the migrasome in tumors, particularly in relation to tumor immunity and tumor microenvironment, is unclear.MethodsGene expression data, copy number variation raw dat...
| Published in: | Frontiers in Immunology |
|---|---|
| Main Authors: | Yan Qin, Jie Yang, Cao Liang, Jun Liu, Zhixing Deng, Binli Yan, Ying Fu, Yinghua Luo, Xiaozhen Li, Xiaoying Wei, Wei Li |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.994828/full |
Similar Items
Migrasome-Related Genes as Potential Prognosis and Immunotherapy Response Predictors for Colorectal Cancer
by: Lu Chang, et al.
Published: (2025-03-01)
by: Lu Chang, et al.
Published: (2025-03-01)
Prognostic significance of migrasomes in neuroblastoma through machine learning and multi-omics
by: Wanrong Li, et al.
Published: (2024-07-01)
by: Wanrong Li, et al.
Published: (2024-07-01)
Exploring PANoptosis in breast cancer based on scRNA-seq and bulk-seq
by: Puxing He, et al.
Published: (2023-06-01)
by: Puxing He, et al.
Published: (2023-06-01)
Comprehensive analysis of single-cell and bulk RNA sequencing data reveals an EGFR signature for predicting immunotherapy response and prognosis in pan-cancer
by: Changchun Ye, et al.
Published: (2025-06-01)
by: Changchun Ye, et al.
Published: (2025-06-01)
Comprehensive identification of a migrasomes-associated long non-coding RNA signature to predict the prognosis and treatment options in colon adenocarcinoma
by: Zhen Zheng, et al.
Published: (2025-03-01)
by: Zhen Zheng, et al.
Published: (2025-03-01)
The roles of migrasome in development
by: Zhaocheng Zhai, et al.
Published: (2024-02-01)
by: Zhaocheng Zhai, et al.
Published: (2024-02-01)
TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression
by: Yue Zheng, et al.
Published: (2023-12-01)
by: Yue Zheng, et al.
Published: (2023-12-01)
Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors
by: Jun Chen, et al.
Published: (2025-05-01)
by: Jun Chen, et al.
Published: (2025-05-01)
Novel insights into the roles of migrasome in cancer
by: Sijun Deng, et al.
Published: (2024-05-01)
by: Sijun Deng, et al.
Published: (2024-05-01)
Integrative bulk and single-cell transcriptomic analysis identifies a migrasome-associated lncRNA signature predictive of prognosis and immune landscape in clear cell renal cell carcinoma
by: Junlin Shen, et al.
Published: (2025-08-01)
by: Junlin Shen, et al.
Published: (2025-08-01)
Migrasomes: key players in immune regulation and promising medical applications
by: Shuping Li, et al.
Published: (2025-05-01)
by: Shuping Li, et al.
Published: (2025-05-01)
Migrasome regulator TSPAN4 shapes the suppressive tumor immune microenvironment in pan-cancer
by: Lin-jian Wang, et al.
Published: (2024-12-01)
by: Lin-jian Wang, et al.
Published: (2024-12-01)
Integrated Single‐Cell RNA‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer
by: Dongwei Li, et al.
Published: (2025-09-01)
by: Dongwei Li, et al.
Published: (2025-09-01)
Inhibition of Aspartate β-Hydroxylase Enhances Anti-Tumor Immunity
by: Johari SD, et al.
Published: (2025-07-01)
by: Johari SD, et al.
Published: (2025-07-01)
Integration of scRNA-Seq and bulk RNA-Seq uncover perturbed immune cell types and pathways of Kawasaki disease
by: Naixin Cao, et al.
Published: (2023-09-01)
by: Naixin Cao, et al.
Published: (2023-09-01)
Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapy
by: Xiashuang Zhao, et al.
Published: (2023-02-01)
by: Xiashuang Zhao, et al.
Published: (2023-02-01)
New techniques: a roadmap for the development of HCC immunotherapy
by: Dizhi Jiang, et al.
Published: (2023-06-01)
by: Dizhi Jiang, et al.
Published: (2023-06-01)
Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma
by: Ao Wang, et al.
Published: (2025-10-01)
by: Ao Wang, et al.
Published: (2025-10-01)
Pan-cancer analysis of IFN-γ with possible immunotherapeutic significance: a verification of single-cell sequencing and bulk omics research
by: Xiaoying Wei, et al.
Published: (2023-08-01)
by: Xiaoying Wei, et al.
Published: (2023-08-01)
Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF
by: Yongfei Hu, et al.
Published: (2025-06-01)
by: Yongfei Hu, et al.
Published: (2025-06-01)
Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry
by: Jian-Di Li, et al.
Published: (2023-12-01)
by: Jian-Di Li, et al.
Published: (2023-12-01)
Migrasome, a novel organelle, differs from exosomes
by: Xun Tan, et al.
Published: (2023-09-01)
by: Xun Tan, et al.
Published: (2023-09-01)
Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk model
by: Yaxuan Liu, et al.
Published: (2023-06-01)
by: Yaxuan Liu, et al.
Published: (2023-06-01)
Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma
by: Tiantian Wang, et al.
Published: (2022-04-01)
by: Tiantian Wang, et al.
Published: (2022-04-01)
Deciphering Innate Immune Cell-Tumor Microenvironment Crosstalk at a Single-Cell Level
by: Ryohichi Sugimura, et al.
Published: (2022-05-01)
by: Ryohichi Sugimura, et al.
Published: (2022-05-01)
Editorial: Community series in the role of angiogenesis and immune response in tumor microenvironment of solid tumor: volume II
by: Haosheng Li, et al.
Published: (2023-11-01)
by: Haosheng Li, et al.
Published: (2023-11-01)
Integrating Primary and Metastatic scRNA–Seq and Bulk Data to Develop an Immune–Based Prognosis Signature for Colorectal Cancer
by: Kaiyuan Xing, et al.
Published: (2025-08-01)
by: Kaiyuan Xing, et al.
Published: (2025-08-01)
Migrasomes and tetraspanins in hepatocellular carcinoma: current status and future prospects
by: Zhongqi Zhang, et al.
Published: (2023-10-01)
by: Zhongqi Zhang, et al.
Published: (2023-10-01)
Integrative multi-omics analysis identifies AEBP1 and EFEMP2 as key regulators of immune heterogeneity and therapeutic response in glioblastoma
by: Yi Yin, et al.
Published: (2025-09-01)
by: Yi Yin, et al.
Published: (2025-09-01)
The Application of Single-Cell RNA Sequencing in the Inflammatory Tumor Microenvironment
by: Jiayi Zhao, et al.
Published: (2023-02-01)
by: Jiayi Zhao, et al.
Published: (2023-02-01)
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model
by: Zhiyong Tan, et al.
Published: (2023-03-01)
by: Zhiyong Tan, et al.
Published: (2023-03-01)
Pan-cancer analysis implicates novel insights of lactate metabolism into immunotherapy response prediction and survival prognostication
by: Dongjie Chen, et al.
Published: (2024-04-01)
by: Dongjie Chen, et al.
Published: (2024-04-01)
A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
by: Zhengquan Wu, et al.
Published: (2023-03-01)
by: Zhengquan Wu, et al.
Published: (2023-03-01)
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
by: Shuping Wei, et al.
Published: (2024-04-01)
by: Shuping Wei, et al.
Published: (2024-04-01)
Dissection of the cell communication interactions in lung adenocarcinoma identified a prognostic model with immunotherapy efficacy assessment and a potential therapeutic candidate gene ITGB1
by: Xing Jin, et al.
Published: (2024-09-01)
by: Xing Jin, et al.
Published: (2024-09-01)
Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics
by: Lihe Jiang, et al.
Published: (2025-01-01)
by: Lihe Jiang, et al.
Published: (2025-01-01)
Single-cell RNA-sequencing data reveals the genetic source of extracellular vesicles in esophageal squamous cell carcinoma
by: Bolun Zhou, et al.
Published: (2023-06-01)
by: Bolun Zhou, et al.
Published: (2023-06-01)
Identification of RNMT as an immunotherapeutic and prognostic biomarker: From pan-cancer analysis to lung squamous cell carcinoma validation
by: Shuqiang Huang, et al.
Published: (2024-09-01)
by: Shuqiang Huang, et al.
Published: (2024-09-01)
Integrative Analysis of scRNA-Seq and Bulk RNA-Seq Identifies Plasma Cell Related Genes and Constructs a Prognostic Model for Hepatocellular Carcinoma
by: Tang M, et al.
Published: (2025-02-01)
by: Tang M, et al.
Published: (2025-02-01)
Novel multi-omics analysis revealing metabolic heterogeneity of breast cancer cell and subsequent development of associated prognostic signature
by: Peng Zhang, et al.
Published: (2025-09-01)
by: Peng Zhang, et al.
Published: (2025-09-01)
Similar Items
-
Migrasome-Related Genes as Potential Prognosis and Immunotherapy Response Predictors for Colorectal Cancer
by: Lu Chang, et al.
Published: (2025-03-01) -
Prognostic significance of migrasomes in neuroblastoma through machine learning and multi-omics
by: Wanrong Li, et al.
Published: (2024-07-01) -
Exploring PANoptosis in breast cancer based on scRNA-seq and bulk-seq
by: Puxing He, et al.
Published: (2023-06-01) -
Comprehensive analysis of single-cell and bulk RNA sequencing data reveals an EGFR signature for predicting immunotherapy response and prognosis in pan-cancer
by: Changchun Ye, et al.
Published: (2025-06-01) -
Comprehensive identification of a migrasomes-associated long non-coding RNA signature to predict the prognosis and treatment options in colon adenocarcinoma
by: Zhen Zheng, et al.
Published: (2025-03-01)
