Age‐stratified machine learning identifies divergent prognostic significance of molecular alterations in AML

Abstract Risk stratification in acute myeloid leukemia (AML) is driven by genetics, yet patient age substantially influences therapeutic decisions. To evaluate how age alters the prognostic impact of genetic mutations, we pooled data from 3062 pediatric and adult AML patients from multiple cohorts....

書誌詳細
出版年:	HemaSphere
主要な著者:	Jan‐Niklas Eckardt, Waldemar Hahn, Rhonda E. Ries, Szymon D. Chrost, Susann Winter, Sebastian Stasik, Christoph Röllig, Uwe Platzbecker, Carsten Müller‐Tidow, Hubert Serve, Claudia D. Baldus, Christoph Schliemann, Kerstin Schäfer‐Eckart, Maher Hanoun, Martin Kaufmann, Andreas Burchert, Johannes Schetelig, Martin Bornhäuser, Markus Wolfien, Soheil Meshinchi, Christian Thiede, Jan Moritz Middeke
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2025-05-01
オンライン･アクセス:	https://doi.org/10.1002/hem3.70132

類似資料

Mimicking clinical trials with synthetic acute myeloid leukemia patients using generative artificial intelligence
著者:: Jan-Niklas Eckardt, 等
出版事項: (2024-03-01)

Prediction of complete remission and survival in acute myeloid leukemia using supervised machine learning
著者:: Jan-Niklas Eckardt, 等
出版事項: (2022-06-01)

Mobilization of PML/RARα negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pre-treated with arsenic trioxide
著者:: Friedrich Stölzel, 等
出版事項: (2010-01-01)

EZH2 mutations and impact on clinical outcome: an analysis in 1,604 patients with newly diagnosed acute myeloid leukemia
著者:: Sebastian Stasik, 等
出版事項: (2020-05-01)

UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome
著者:: Julia-Annabell Georgi, 等
出版事項: (2023-05-01)

Validation of the revised 2022 European LeukemiaNet risk stratification in adult patients with acute myeloid leukemia
著者:: Leo Ruhnke, 等
出版事項: (2025-03-01)

S138: VALIDATION OF THE REVISED 2022 EUROPEAN LEUKEMIANET (ELN) RISK STRATIFICATION IN ADULT PATIENTS WITH ACUTE MYELOID LEUKEMIA
著者:: Marius Bill, 等
出版事項: (2023-08-01)

Induction of short-term remission with single agent eltrombopag in refractory nucleophosmin-1-mutated acute myeloid leukemia
著者:: Uwe Platzbecker, 等
出版事項: (2014-12-01)

Synthetic bone marrow images augment real samples in developing acute myeloid leukemia microscopy classification models
著者:: Jan-Niklas Eckardt, 等
出版事項: (2025-03-01)

Midostaurin in addition to intensive chemotherapy in acute myeloid leukemia with t(8;21) and <i>KIT</i> and/or <i>FLT3</i>- ITD mutations: results of the SAL MIDOKIT trial
著者:: Leo Ruhnke, 等
出版事項: (2023-02-01)

P490: SNORNA-DERIVED RNAS (SDRNAS) ARE IMPORTANT DRIVERS OF LEUKEMOGENESIS AND LEUKEMIC MAINTENANCE IN AML
著者:: R. Zinz, 等
出版事項: (2022-06-01)

Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens
著者:: David Baden, 等
出版事項: (2024-04-01)

P554: RESULTS OF A RANDOMIZED PLACEBO-CONTROLLED PHASE 2 STUDY OF HYPOMETHYLATING AGENTS WITH OR WITHOUT ELTROMBOPAG IN ELDERLY AML PATIENTS (DELTA)
著者:: Katja Sockel, 等
出版事項: (2023-08-01)

Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia
著者:: Sabine Kayser, 等
出版事項: (2023-02-01)

Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML
著者:: Julia M. Unglaub, 等
出版事項: (2025-01-01)

How to customize common data models for rare diseases: an OMOP-based implementation and lessons learned
著者:: Najia Ahmadi, 等
出版事項: (2024-08-01)

P545: CHARACTERISTICS AND OUTCOME OF PATIENTS WITH ACUTE MYELOID LEUKEMIA AND TRISOMY 19
著者:: S. Kayser, 等
出版事項: (2022-06-01)

Impaired Overall Survival in Young Patients With Acute Myeloid Leukemia and Variants in Genes Predisposing for Myeloid Malignancies
著者:: Martin Kirschner, 等
出版事項: (2022-11-01)

Dynamics of epigenetic age following hematopoietic stem cell transplantation
著者:: Friedrich Stölzel, 等
出版事項: (2017-08-01)

The prevalence of extramedullary acute myeloid leukemia detected by 18FDG-PET/CT: final results from the prospective PETAML trial
著者:: Friedrich Stölzel, 等
出版事項: (2020-06-01)

18F-FDG-PET/CT for detection of extramedullary acute myeloid leukemia
著者:: Friedrich Stölzel, 等
出版事項: (2011-10-01)

P404: PROGNOSTIC IMPACT OF CEBPA-MUTATIONAL SUBGROUPS IN ADULT AML – RESULTS OF A LARGE METAANALYSIS IN MORE THAN 1000 CEBPA-MUTANT PATIENTS
著者:: J.-A. Georgi, 等
出版事項: (2022-06-01)

Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study
著者:: Elke Rücker-Braun, 等
出版事項: (2025-06-01)

Spatial heterogeneity and differential treatment response of acute myeloid leukemia and relapsed/refractory extramedullary disease after allogeneic hematopoietic cell transplantation
著者:: Desiree Kunadt, 等
出版事項: (2022-08-01)

Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4
著者:: Sabine Kayser, 等
出版事項: (2022-06-01)

Second donation of hematopoietic stem cells from unrelated donors for patients with relapse or graft failure after allogeneic transplantation
著者:: Uwe Platzbecker, 等
出版事項: (2008-08-01)

A scoring system for AML patients aged 70 years or older, eligible for intensive chemotherapy: a study based on a large European data set using the DATAML, SAL, and PETHEMA registries
著者:: Emilie Bérard, 等
出版事項: (2022-07-01)

Minimal residual disease-directed preemptive treatment with azacitidine in patients with NPM1-mutant acute myeloid leukemia and molecular relapse
著者:: Katja Sockel, 等
出版事項: (2011-10-01)

T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing
著者:: Cornelia S. Link-Rachner, 等
出版事項: (2019-03-01)

Q-HAM: a multicenter upfront randomized phase II trial of quizartinib and high-dose Ara-C plus mitoxantrone in relapsed/refractory AML with FLT3-ITD
著者:: Sonia Jaramillo, 等
出版事項: (2023-09-01)

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study.
著者:: Utz Krug, 等
出版事項: (2012-01-01)

Real-world experience with first-line CPX-351 treatment in patients with acute myeloid leukemia – long-term follow-up with focus on younger patients
著者:: Christina Rautenberg, 等
出版事項: (2025-04-01)

P556: A NEW MULTIPLEX PCR TOOL ENABLES TIMELY IDENTIFICATION OF ACTIONABLE TARGETS FOR MOLECULAR-GUIDED THERAPY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA
著者:: Friedrich Stölzel, 等
出版事項: (2023-08-01)

Randomized phase III GnG study on two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and double-blinded intensive postremission therapy with or without glasdegib in patients with newly diagnosed acute myeloid leukemia
著者:: Sonia Jaramillo, 等
出版事項: (2024-02-01)

An open-label, phase I/II trial to determine the maximum tolerated dose and investigate safety, pharmacokinetics and efficacy of BI 836858, an unconjugated anti-CD33 monoclonal antibody, in combination with decitabine in patients with acute myeloid leukemia
著者:: Walter Fiedler, 等
出版事項: (2022-08-01)

Gastrointestinal toxicity of gemtuzumab ozogamicin: real-life data from the AMLCG, SAL, and CELL study groups
著者:: Ricarda Knabe, 等
出版事項: (2025-07-01)

Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
著者:: Martin Bornhäuser, 等
出版事項: (2009-11-01)

P528: CAN MULTIPARAMETRIC FLOW CYTOMETRY OF PERIPHERAL BLOOD CHALLENGE BONE MARROW ANALYSES FOR DETECTION OF MEASURABLE RESIDUAL DISEASE IN PATIENTS WITH ACUTE MYELOID LEUKEMIA?
著者:: Jonas Schadt, 等
出版事項: (2023-08-01)

Spirituality and Religiousness of Secondary School Students in a Public and Catholic School
著者:: Marzena Chrost, 等
出版事項: (2024-06-01)

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study
著者:: Sabine Kayser, 等
出版事項: (2021-05-01)