| الملخص: | This study was conducted to explore the effects of the joint application of <i>Lactobacillus plantarum</i> and <i>Bacillus subtilis</i> on growth performance, immune function, antioxidant capacity, intestinal integrity, and gut microbiota composition in weaned piglets. The piglets were allocated randomly into 4 dietary groups, which were a control diet (NC), NC + 150 ppm mucilage sulfate (PC), and 3 additional diets containing 1 kg/t (LT), 1.5 kg/t (MT), or 2 kg/t (HT) mixture of <i>Lactobacillus plantarum</i> and <i>Bacillus subtilis</i>, respectively. Results showed that joint application of <i>Lactobacillus plantarum</i> and <i>Bacillus subtilis</i> increased ADFI and ADG of weaned piglets in d 14~28 and d 28~42 (<i>p</i> < 0.05), and decreased serum concentrations of DAO, IL-1β, TNF-α, and IL-2. The LT group increased jejunal and colonic sIgA contents compared with the PC group (<i>p</i> < 0.05). Groups of MT and HT increased colonic mRNA expression of host defense peptides and tight junction proteins compared with the NC and PC groups. The joint application of <i>Lactobacillus plantarum</i> and <i>Bacillus subtilis</i> increased the abundance of colonic <i>Lactobacillus</i> compared with NC and PC groups (<i>p</i> < 0.10). In conclusion, the joint application of <i>Lactobacillus plantarum</i> and <i>Bacillus subtilis</i> as an antibiotics alternative improved growth performance via promoting immune function and intestinal integrity of weaned piglets.
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