Engineered Vasculature for Organ-on-a-Chip Systems
Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ in the human body, plays a crucial role in ox...
| Published in: | Engineering |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-02-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809921003337 |
| _version_ | 1849324066430779392 |
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| author | Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang Huayong Yang |
| author_facet | Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang Huayong Yang |
| author_sort | Abdellah Aazmi |
| collection | DOAJ |
| container_title | Engineering |
| description | Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ in the human body, plays a crucial role in oxygen exchange and mass transfer, which is the determining factor for the survival of tissues and organs. Thus, it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological functions. This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology, which offers even better possibilities of duplicating physiology and disease characteristics. In addition, we review the different steps of a vascularized organ-on-a-chip fabrication process, including structure fabrication and tissue construction using different biofabrication strategies. Finally, we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture. |
| format | Article |
| id | doaj-art-2bc42e178b034a0aa2036bbca4893870 |
| institution | Directory of Open Access Journals |
| issn | 2095-8099 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-2bc42e178b034a0aa2036bbca48938702025-09-02T04:58:08ZengElsevierEngineering2095-80992022-02-01913114710.1016/j.eng.2021.06.020Engineered Vasculature for Organ-on-a-Chip SystemsAbdellah Aazmi0Hongzhao Zhou1Yuting Li2Mengfei Yu3Xiaobin Xu4Yutong Wu5Liang Ma6Bin Zhang7Huayong Yang8State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, ChinaThe Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaSchool of Materials Science and Engineering, Tongji University, Shanghai 201804, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China; Corresponding authors.State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China; Corresponding authors.Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ in the human body, plays a crucial role in oxygen exchange and mass transfer, which is the determining factor for the survival of tissues and organs. Thus, it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological functions. This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology, which offers even better possibilities of duplicating physiology and disease characteristics. In addition, we review the different steps of a vascularized organ-on-a-chip fabrication process, including structure fabrication and tissue construction using different biofabrication strategies. Finally, we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture.http://www.sciencedirect.com/science/article/pii/S2095809921003337Organ-on-a-chipVasculatureBioprintingTumor-on-a-chip |
| spellingShingle | Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang Huayong Yang Engineered Vasculature for Organ-on-a-Chip Systems Organ-on-a-chip Vasculature Bioprinting Tumor-on-a-chip |
| title | Engineered Vasculature for Organ-on-a-Chip Systems |
| title_full | Engineered Vasculature for Organ-on-a-Chip Systems |
| title_fullStr | Engineered Vasculature for Organ-on-a-Chip Systems |
| title_full_unstemmed | Engineered Vasculature for Organ-on-a-Chip Systems |
| title_short | Engineered Vasculature for Organ-on-a-Chip Systems |
| title_sort | engineered vasculature for organ on a chip systems |
| topic | Organ-on-a-chip Vasculature Bioprinting Tumor-on-a-chip |
| url | http://www.sciencedirect.com/science/article/pii/S2095809921003337 |
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