Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest
Background: Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called “life-saving systems”. These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in...
| Published in: | Resuscitation Plus |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520424000158 |
| _version_ | 1850325225978200064 |
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| author | Michael P. Müller Julian Ganter Hans-Jörg Busch Georg Trummer Jörg Sahlmann Florian Brettner Maria Reden Daniel Elschenbroich Michael Preusch Jonas Rusnak Stephan Katzenschlager Dirk Nauheimer Robert Wunderlich Jan-Steffen Pooth |
| author_facet | Michael P. Müller Julian Ganter Hans-Jörg Busch Georg Trummer Jörg Sahlmann Florian Brettner Maria Reden Daniel Elschenbroich Michael Preusch Jonas Rusnak Stephan Katzenschlager Dirk Nauheimer Robert Wunderlich Jan-Steffen Pooth |
| author_sort | Michael P. Müller |
| collection | DOAJ |
| container_title | Resuscitation Plus |
| description | Background: Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called “life-saving systems”. These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in proximity of a suspected out-of-hospital cardiac arrest (OHCA). However, the effect of SAS on survival remains unknown. Aim: The aim is to assess the rate of survival to hospital discharge in adult patients with OHCA not witnessed by emergency medical services (EMS): before and after SAS implementation. Design: Multicentre, prospective, observational, intention-to-treat, pre–post design clinical trial. Population: Adults (aged ≥ 18 years), OHCA not witnessed by EMS, no traumatic cause for cardiac arrest, cardiopulmonary resuscitation initiated or continued by EMS. Setting: Dispatch-centre-based. Outcomes: Primary: survival to hospital discharge. Secondary: time to first compression, rate of basic life support measures before EMS arrival, rate of patients with shockable rhythm at EMS arrival, Cerebral Performance Category at hospital discharge, and duration of hospital stay. Sample size: Assuming an absolute difference in survival rates to hospital discharge of 4% in the two groups (11% before implementation of the SAS versus 15% after) and 80% power, and a type 1 error rate of 0.05, the required sample size is N = 1,109 patients per group (at least N = 2,218 evaluated patients in total). Conclusions: The HEROES trial will investigate the effects of a SAS on the survival rate after OHCA. Trial registration: German Clinical Trials Register (DRKS, ID: DRKS00032920) |
| format | Article |
| id | doaj-art-2bde8c4e550b4814ab5a6e1b8a5b1eec |
| institution | Directory of Open Access Journals |
| issn | 2666-5204 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-2bde8c4e550b4814ab5a6e1b8a5b1eec2025-08-19T23:21:02ZengElsevierResuscitation Plus2666-52042024-03-011710056410.1016/j.resplu.2024.100564Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrestMichael P. Müller0Julian Ganter1Hans-Jörg Busch2Georg Trummer3Jörg Sahlmann4Florian Brettner5Maria Reden6Daniel Elschenbroich7Michael Preusch8Jonas Rusnak9Stephan Katzenschlager10Dirk Nauheimer11Robert Wunderlich12Jan-Steffen Pooth13Department of Anaesthesiology, Intensive Care and Emergency Medicine, St. Josefs Hospital, Freiburg, Germany; Corresponding author at: Prof. Dr. Michael P. Müller, Department of Anaesthesiology, Intensive Care and Emergency Medicine, St. Josefs Hospital, Sautierstrasse 1, 79104 Freiburg/ Germany.Department of Anaesthesiology and Critical Care, Medical Centre – University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Emergency Medicine, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Cardiovascular Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyInstitute of Medical Biometry and Statistics (IMBI), Faculty of Medicine − University Medical Center Freiburg, Freiburg, GermanyDepartment of Anaesthesiology and Intensive Care Medicine, Barmherzige Brüder Hospital St. Barbara, Schwandorf, GermanyDepartment of Anaesthesiology and Intensive Care, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyCharite Universitätsmedizin Berlin, Corporate Member of Freie Unversität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Internal Medicine III, Intensive Care, University of Heidelberg Heidelberg, GermanyDepartment of Internal Medicine III, Intensive Care, University of Heidelberg Heidelberg, GermanyDepartment of Anesthesiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, GermanyHeart Center Trier, Krankenhaus der Barmherzigen Brüder, Trier, GermanyUniversity Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University, Tübingen, GermanyDepartment of Emergency Medicine, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyBackground: Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called “life-saving systems”. These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in proximity of a suspected out-of-hospital cardiac arrest (OHCA). However, the effect of SAS on survival remains unknown. Aim: The aim is to assess the rate of survival to hospital discharge in adult patients with OHCA not witnessed by emergency medical services (EMS): before and after SAS implementation. Design: Multicentre, prospective, observational, intention-to-treat, pre–post design clinical trial. Population: Adults (aged ≥ 18 years), OHCA not witnessed by EMS, no traumatic cause for cardiac arrest, cardiopulmonary resuscitation initiated or continued by EMS. Setting: Dispatch-centre-based. Outcomes: Primary: survival to hospital discharge. Secondary: time to first compression, rate of basic life support measures before EMS arrival, rate of patients with shockable rhythm at EMS arrival, Cerebral Performance Category at hospital discharge, and duration of hospital stay. Sample size: Assuming an absolute difference in survival rates to hospital discharge of 4% in the two groups (11% before implementation of the SAS versus 15% after) and 80% power, and a type 1 error rate of 0.05, the required sample size is N = 1,109 patients per group (at least N = 2,218 evaluated patients in total). Conclusions: The HEROES trial will investigate the effects of a SAS on the survival rate after OHCA. Trial registration: German Clinical Trials Register (DRKS, ID: DRKS00032920)http://www.sciencedirect.com/science/article/pii/S2666520424000158Cardiopulmonary resuscitationFirst responder systemSmartphone alerting systemOut-of-hospital cardiac arrest |
| spellingShingle | Michael P. Müller Julian Ganter Hans-Jörg Busch Georg Trummer Jörg Sahlmann Florian Brettner Maria Reden Daniel Elschenbroich Michael Preusch Jonas Rusnak Stephan Katzenschlager Dirk Nauheimer Robert Wunderlich Jan-Steffen Pooth Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest Cardiopulmonary resuscitation First responder system Smartphone alerting system Out-of-hospital cardiac arrest |
| title | Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest |
| title_full | Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest |
| title_fullStr | Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest |
| title_full_unstemmed | Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest |
| title_short | Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest |
| title_sort | out of hospital cardiac arrest amp smartphone responders trial heroes trial methodology and study protocol of a pre post design trial of the effect of implementing a smartphone alerting system on survival in out of hospital cardiac arrest |
| topic | Cardiopulmonary resuscitation First responder system Smartphone alerting system Out-of-hospital cardiac arrest |
| url | http://www.sciencedirect.com/science/article/pii/S2666520424000158 |
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