Bcl-XL inhibits membrane permeabilization by competing with Bax.

Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process. Two different models of Bcl-XL function have been proposed. In one, Bcl-XL binds to a...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	PLoS Biology
المؤلفون الرئيسيون:	Lieven P Billen, Candis L Kokoski, Jonathan F Lovell, Brian Leber, David W Andrews
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Public Library of Science (PLoS) 2008-06-01
الوصول للمادة أونلاين:	http://europepmc.org/articles/PMC2422857?pdf=render

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