Alkaline Phosphatase, an Unconventional Immune Protein

Recent years have seen an increase in the number of studies focusing on alkaline phosphatases (APs), revealing an expanding complexity of function of these enzymes. Of the four human AP (hAP) proteins, most is known about tissue non-specific AP (TNAP) and intestinal AP (IAP). This review highlights...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Author:	Bethany A. Rader
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Subjects:	alkaline phosphatase hypophosphatasia tissue non-specific AP intestinal AP lipopolysaccharide microbiome
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00897/full

Similar Items

FINDING HYPOPHOSPHASIA. LOW LEVEL OF ALKALINE PHOSPHATASE PATIENTS SCREENING
by: A. V. Vitebskaya, et al.
Published: (2017-12-01)

Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications
by: Iliass Imam, et al.
Published: (2024-11-01)

Short stature with low serum alkaline phosphatase activity: a case report of hypophosphatasia
by: Donghyun Lee, et al.
Published: (2023-12-01)

The lipopolysaccharide structure affects the detoxifying ability of intestinal alkaline phosphatases
by: Bjarne Vermeire, et al.
Published: (2024-08-01)

Hypophosphatasia in Taiwan: Report of Two Cases
by: Yen-Yin Chou, et al.
Published: (2005-03-01)

Intestinal alkaline phosphatase (IAP, IAP Enhancer) attenuates intestinal inflammation and alleviates insulin resistance
by: Chenzhe Gao, et al.
Published: (2022-07-01)

Deglycosylation Differentially Regulates Weaned Porcine Gut Alkaline Phosphatase Isoform Functionality along the Longitudinal Axis
by: Xindi Yin, et al.
Published: (2023-03-01)

Neurological and Neurosurgical Aspects of Hypophosphatasia
by: Vadim P. Ivanov, et al.
Published: (2018-07-01)

Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene
by: Luis Martínez-Heredia, et al.
Published: (2024-01-01)

Hypophosphatasia: A Novel Mutation Associated with an Atypical Newborn Presentation
by: Roger Esmel-Vilomara, et al.
Published: (2020-03-01)

Effectiveness and safety of asfotase alfa for people with hypophosphatasia: a plain language summary of three studies
by: Fatma Al Jasmi, et al.
Published: (2025-03-01)

Two novel mutations in the ALPL gene of unrelated Chinese children with Hypophosphatasia: case reports and literature review
by: Xiaojian Mao, et al.
Published: (2019-11-01)

Multiple fractures, pain, and severe disability in a patient with adult-onset hypophosphatasia
by: Neil A. Braunstein
Published: (2016-06-01)

Hypophosphatasia: literature review and description of a clinical case of familial disease with molecular genetic verification of the diagnosis
by: E. Yu. Belyashova, et al.
Published: (2023-02-01)

Modern Approaches to the Management of Children with Hypophosphatasia
by: Aleksander A. Baranov, et al.
Published: (2023-08-01)

Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark
by: Nicola Hepp, et al.
Published: (2021-12-01)

Adult hypophosphatasia with a novel ALPL mutation: Report of an Indian kindred
by: Sanjay K. Bhadada, et al.
Published: (2020-06-01)

Multigenerational genetic inheritance and clinical characteristics of the rare disease hypophosphatasia in 6 families: A case series
by: Peter Kannu, et al.
Published: (2025-09-01)

Safety and efficacy of long term asfotase alfa treatment in childhood hypophosphatasia
by: Debora Mariarita d’Angelo, et al.
Published: (2025-03-01)

Hypophosphatasia: from birth to adulthood
by: Fernanda Salles Reis, et al.
Published: (2023-06-01)

Role of Intestinal Alkaline Phosphatase in Innate Immunity
by: Sudha B. Singh, et al.
Published: (2021-11-01)

Intestinal alkaline phosphatase improves intestinal permeability and alleviates multiple organ dysfunction caused by heatstroke
by: Zhen Luo, et al.
Published: (2023-11-01)

A case report of unsuccessful enzyme replacement therapy in perinatal hypophosphatasia: impact of comorbid tetralogy of Fallot, prematurity, and novel variants
by: Tram Le, et al.
Published: (2025-09-01)

Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?
by: C. Tornero, et al.
Published: (2020-02-01)

Lifetime follow-up of an adult patient with pediatric-onset hypophosphatasia complicated with advanced chronic kidney disease
by: Maria Sääf, et al.
Published: (2025-09-01)

Hiperfosfatasemia transitória benigna da infância Benign transient hyperphosphatasemia of childhood
by: Crésio Alves, et al.
Published: (2009-01-01)

A Japanese single-center experience of the efficacy and safety of asfotase alfa in pediatric-onset hypophosphatasia
by: Yohei Sugiyama, et al.
Published: (2022-02-01)

Radiological evaluation of pseudofracture after the administration of asfotase alfa in an adult with benign prenatal hypophosphatasia: A case report
by: Hajime Kato, et al.
Published: (2022-06-01)

INVESTIGATION OF ALKALINE PHOSPHATASE EXPRESSION IN THE SMALL INTESTINES OF THE BRONZE TURKEY (MELEAGRIS GALLOPAVO)
by: D. Yovchev, et al.
Published: (2020-12-01)

STUDY OF SEMINAL ACID PHOSPHATASE AND ALKALINE PHOSPHATASE LEVEL IN RELATION TO SPERM COUNT IN TEACHING HOSPITAL
by: Nayak Jitendra, et al.
Published: (2015-12-01)

Can bone-specific alkaline phosphatase be a marker of vascular calcification in type 2 diabetes mellitus?
by: Nishant Raizada, et al.
Published: (2023-01-01)

Japanese nationwide dental survey of hypophosphatasia reveals novel oral manifestations
by: Rena Okawa, et al.
Published: (2025-02-01)

First Reported Case of a Pyrophosphate Kidney Stone in a Human
by: Michael R. Gigax, et al.
Published: (2023-09-01)

Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry
by: Wolfgang Högler, et al.
Published: (2019-02-01)

Hypophosphatasia and its role in bone pathology in adults
by: K. E. Zotkina, et al.
Published: (2021-06-01)

Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease
by: Burcu Berberoğlu Ateş, et al.
Published: (2022-12-01)

Multiple Myeloma and Alkaline Phosphatase
by: İrfan Yavaşoğlu, et al.
Published: (2015-05-01)

Deletion of the Pyrophosphate Generating Enzyme ENPP1 Rescues Craniofacial Abnormalities in the TNAP−/− Mouse Model of Hypophosphatasia and Reveals FGF23 as a Marker of Phenotype Severity
by: Hwa Kyung Nam, et al.
Published: (2022-04-01)

The effects of chromium and cadmium on the activity of alkaline phosphatase lsoenzmes in rats
by: S.A.A Moshtaghi, et al.
Published: (1995-09-01)

SPICES AND THEIR INFLUENCE ON THE ACTIVITY OF INTESTINAL PHOSPHATASES
by: Amenah Jafarey, et al.
Published: (2019-04-01)