| Summary: | Autophagy is a lysosomal dependent degradation system, and p62 itself is an importantprotein carrier to facilitate the removal of damaged proteins by proteasomes and autophagosomes. p62 playsan important role in selective autophagy such as mitochondrial autophagy. p62 binds to Keap1 and clearsKeap1 through autophagy, leading to increased levels of free Nrf2. Nrf2 can promote the expression of p62,glutathione (GSH) and thioredoxin (TXN). Therefore, autophagy, p62 and Nrf2 are closely related and mutuallyregulated. However, in the process of hepatic ischemia-reperfusion injury, these molecules in hepatocytesmay participate in the process of cell death, and the specific mechanism still needs to be further studied.
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