An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report
Primary renal Ewing sarcoma/primitive neuroectodermal tumor (PNET) is a very rare and aggressive malignant tumor. We report a case of a young adult who presented with painless hematuria and acute urinary retention and was subsequently diagnosed with localized left renal Ewing sarcoma following robot...
| 出版年: | Frontiers in Oncology |
|---|---|
| 主要な著者: | , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media S.A.
2025-09-01
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| 主題: | |
| オンライン･アクセス: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1602774/full |
| _version_ | 1849289661696966656 |
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| author | Wei Lun Tan Iqbal Hussain Rizuana Bang Rom Lee Xeng Inn Fam |
| author_facet | Wei Lun Tan Iqbal Hussain Rizuana Bang Rom Lee Xeng Inn Fam |
| author_sort | Wei Lun Tan |
| collection | DOAJ |
| container_title | Frontiers in Oncology |
| description | Primary renal Ewing sarcoma/primitive neuroectodermal tumor (PNET) is a very rare and aggressive malignant tumor. We report a case of a young adult who presented with painless hematuria and acute urinary retention and was subsequently diagnosed with localized left renal Ewing sarcoma following robotic-assisted retroperitoneal partial nephrectomy. Histopathology revealed a tumor composed of nests and lobules of monotonous tumor cells with round nuclei, indistinct nucleoli, and scanty cytoplasm, associated with a vascular-rich to hyalinized stroma and fibrillary neural matrix. Moderate nuclear pleomorphism, scattered necrosis, and pseudorosette formation were noted. Immunohistochemical studies demonstrated tumor cell positivity for CD99 and CD117. The patient was subjected to chemotherapy. Early diagnosis and multimodality treatment play an important role in improving survival rate. |
| format | Article |
| id | doaj-art-2daaee96abb44462aaed8dbfd8a43e64 |
| institution | Directory of Open Access Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-2daaee96abb44462aaed8dbfd8a43e642025-09-09T04:15:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-09-011510.3389/fonc.2025.16027741602774An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case reportWei Lun Tan0Iqbal Hussain Rizuana1Bang Rom Lee2Xeng Inn Fam3Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Pathology, Hospital Picaso, Petaling Jaya, MalaysiaUrology Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaPrimary renal Ewing sarcoma/primitive neuroectodermal tumor (PNET) is a very rare and aggressive malignant tumor. We report a case of a young adult who presented with painless hematuria and acute urinary retention and was subsequently diagnosed with localized left renal Ewing sarcoma following robotic-assisted retroperitoneal partial nephrectomy. Histopathology revealed a tumor composed of nests and lobules of monotonous tumor cells with round nuclei, indistinct nucleoli, and scanty cytoplasm, associated with a vascular-rich to hyalinized stroma and fibrillary neural matrix. Moderate nuclear pleomorphism, scattered necrosis, and pseudorosette formation were noted. Immunohistochemical studies demonstrated tumor cell positivity for CD99 and CD117. The patient was subjected to chemotherapy. Early diagnosis and multimodality treatment play an important role in improving survival rate.https://www.frontiersin.org/articles/10.3389/fonc.2025.1602774/fullrenal Ewing sarcomaprimitive neuroectodermal tumor (PNET)laparoscopic nephrectomychemotherapycase report |
| spellingShingle | Wei Lun Tan Iqbal Hussain Rizuana Bang Rom Lee Xeng Inn Fam An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report renal Ewing sarcoma primitive neuroectodermal tumor (PNET) laparoscopic nephrectomy chemotherapy case report |
| title | An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report |
| title_full | An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report |
| title_fullStr | An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report |
| title_full_unstemmed | An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report |
| title_short | An exceptional oncological enigma: primary renal Ewing sarcoma in a clinical context—a case report |
| title_sort | exceptional oncological enigma primary renal ewing sarcoma in a clinical context a case report |
| topic | renal Ewing sarcoma primitive neuroectodermal tumor (PNET) laparoscopic nephrectomy chemotherapy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1602774/full |
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