Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis
Esophageal cancer (EC) is an aggressive malignancy with a poor prognosis. Various factors, including dietary habits, and antacid and antibiotic use, have been shown to influence the esophageal microbiome. Conversely, enrichment and diversity of the esophageal microbiome can also impact its function....
| الحاوية / القاعدة: | Cancer Biology & Medicine |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
China Anti-Cancer Association
2024-02-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.cancerbiomed.org/content/21/2/163 |
| _version_ | 1850049636264312832 |
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| author | Yi Li Bing Wei Xia Xue Hongle Li Jun Li |
| author_facet | Yi Li Bing Wei Xia Xue Hongle Li Jun Li |
| author_sort | Yi Li |
| collection | DOAJ |
| container_title | Cancer Biology & Medicine |
| description | Esophageal cancer (EC) is an aggressive malignancy with a poor prognosis. Various factors, including dietary habits, and antacid and antibiotic use, have been shown to influence the esophageal microbiome. Conversely, enrichment and diversity of the esophageal microbiome can also impact its function. Recent studies have revealed prevalent changes in the esophageal microbiome among patients with EC, thus suggesting the potential contribution of the esophageal microbiome to EC development. Additionally, distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy, indicating the role of the esophageal microbiome in modulating treatment outcomes. In this review, we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases, with a focus on identifying microbial communities associated with EC pathogenesis and prognosis. Understanding the role of the microbiome in EC may aid in early detection and optimized treatment strategies, ultimately leading to better outcomes for patients. |
| format | Article |
| id | doaj-art-2e0662ef287c416c8335f0710cb9fb07 |
| institution | Directory of Open Access Journals |
| issn | 2095-3941 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| spelling | doaj-art-2e0662ef287c416c8335f0710cb9fb072025-08-20T00:27:30ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412024-02-0121216317410.20892/j.issn.2095-3941.2023.0177Microbiome changes in esophageal cancer: implications for pathogenesis and prognosisYi Li0Bing Wei1Xia Xue2Hongle Li3Jun Li4Department of Molecular Pathology, Clinical Pathology Center, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou 450003, ChinaDepartment of Molecular Pathology, Clinical Pathology Center, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou 450003, ChinaHenan Key Laboratory of Helicobacter pylori & Microbiota and Gastrointestinal Cancer, Marshall Medical Research Center, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Molecular Pathology, Clinical Pathology Center, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou 450003, ChinaDepartment of Molecular Pathology, Clinical Pathology Center, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou 450003, ChinaEsophageal cancer (EC) is an aggressive malignancy with a poor prognosis. Various factors, including dietary habits, and antacid and antibiotic use, have been shown to influence the esophageal microbiome. Conversely, enrichment and diversity of the esophageal microbiome can also impact its function. Recent studies have revealed prevalent changes in the esophageal microbiome among patients with EC, thus suggesting the potential contribution of the esophageal microbiome to EC development. Additionally, distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy, indicating the role of the esophageal microbiome in modulating treatment outcomes. In this review, we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases, with a focus on identifying microbial communities associated with EC pathogenesis and prognosis. Understanding the role of the microbiome in EC may aid in early detection and optimized treatment strategies, ultimately leading to better outcomes for patients.https://www.cancerbiomed.org/content/21/2/163esophageal cancermicrobiomedysbiosismicroenvironmentcarcinogenesis |
| spellingShingle | Yi Li Bing Wei Xia Xue Hongle Li Jun Li Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis esophageal cancer microbiome dysbiosis microenvironment carcinogenesis |
| title | Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis |
| title_full | Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis |
| title_fullStr | Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis |
| title_full_unstemmed | Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis |
| title_short | Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis |
| title_sort | microbiome changes in esophageal cancer implications for pathogenesis and prognosis |
| topic | esophageal cancer microbiome dysbiosis microenvironment carcinogenesis |
| url | https://www.cancerbiomed.org/content/21/2/163 |
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