Rapid Remission of Sunburn-Induced Guttate Psoriasis with Guselkumab

• Published in: Dermatology and Therapy
• Main Authors: Erin Bartholomew, Bo-Young Chung, Mitchell Davis, Samuel Yeroushalmi, Mimi Chung, Marwa Hakimi, Tina Bhutani, Wilson Liao
• Format: Article
• Language: English
• Published: Adis, Springer Healthcare 2023-09-01
• Subjects: Guttate psoriasis; Guselkumab; Sunburn; Anti-IL23; Monoclonal antibody; Remission
• Online Access: https://doi.org/10.1007/s13555-023-01013-y

Abstract Guselkumab is an anti-interleukin-23 monoclonal antibody that is approved for plaque psoriasis and psoriatic arthritis. We present a case of a 28-year-old female patient with acute onset of guttate psoriasis after a blistering sunburn. She had no personal or family history of psoriasis or chronic inflammatory skin disease. The guttate psoriasis was refractory to topical treatment. After the first dose of guselkumab (100 mg subcutaneous injection), the patient experienced near-clearance of her guttate psoriasis, with continued improvement and drug-free remission 8 months after cessation of treatment. Dermatologists could consider guselkumab as a treatment option for patients with guttate psoriasis. Future studies should examine the potential for guselkumab to induce drug-free remissions in guttate psoriasis.