FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms

Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger oxidative stress have been heavily implicated in...

Full description

Bibliographic Details
Published in:	Redox Biology
Main Authors:	Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725000400

Similar Items

Corrigendum to “FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms” [Redox Biol. 80 (2025) 103527]
by: Manish Kumar, et al.
Published: (2025-09-01)

RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21
by: Abhishek Singh Sengar, et al.
Published: (2024-02-01)

FNDC5/Irisin: Physiology and Pathophysiology
by: Rashid Waseem, et al.
Published: (2022-02-01)

The Role of FNDC5/Irisin in Cardiovascular Disease
by: Maciej Grzeszczuk, et al.
Published: (2024-02-01)

RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis
by: Kiran Das, et al.
Published: (2022-11-01)

The role of exercise-related FNDC5/irisin in depression
by: Yaqi Liu, et al.
Published: (2024-10-01)

FNDC5/Irisin in dementia and cognitive impairment: update and novel perspective
by: Xiaofeng Guo, et al.
Published: (2024-07-01)

Cardiotoxicity in chemotherapeutic agents
by: Vitorino Modesto dos Santos, et al.
Published: (2021-03-01)

Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis
by: Lorenzo Sanesi, et al.
Published: (2023-01-01)

Lack of Association Between FNDC5 Gene Polymorphisms, Serum Irisin Levels and Allergic Rhinitis
by: Hüseyin Günizi, et al.
Published: (2023-10-01)

Irisin regulates pancreatic lipases through PPARγ-PGCα-FNDC5 pathway
by: Horwitz Avital, et al.
Published: (2023-01-01)

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner
by: Anika Shimonty, et al.
Published: (2024-04-01)

Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?
by: Mohammad Hosseinzadeh, et al.
Published: (2018-04-01)

FNDC5/irisin mediates the protective effects of Innovative theta-shaking exercise on mouse memory
by: Runhong Yao, et al.
Published: (2024-04-01)

Cystine-cored diphenylalanine appended peptide-based self-assembled fluorescent nanostructures direct redox-responsive drug delivery
by: Suman Nayak, et al.
Published: (2024-04-01)

Evolutionary Insights into Irisin/FNDC5: Roles in Aging and Disease from <i>Drosophila</i> to Mammals
by: Kiwon Lee, et al.
Published: (2025-02-01)

Cardiotoxic effects of chemotherapeutical treatment in oncological patient
by: D. P. Kotova, et al.
Published: (2019-04-01)

Exercise-Induced FNDC5/Irisin Ameliorates Cognitive Impairment in Aged Mice, Associated with Antioxidant and Neurotrophic Responses
by: Jae Min Lee, et al.
Published: (2025-10-01)

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
by: Songling Jiang, et al.
Published: (2021-02-01)

MODERN VIEW ON CARDIOTOXICITY OF CHEMOTHERAPEUTICS IN ONCOLOGY INCLUDING ANTHRACYCLINES
by: G. E. Gendlin, et al.
Published: (2017-03-01)

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis
by: Qianqian Dong, et al.
Published: (2024-03-01)

FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise
by: Min-Zhi Mao, et al.
Published: (2025-07-01)

Dietary Intervention, When Not Associated With Exercise, Upregulates Irisin/FNDC5 While Reducing Visceral Adiposity Markers in Obese Rats
by: Vanessa de Oliveira Furino, et al.
Published: (2021-08-01)

Cardiotoxicity of Chemotherapeutic Drugs (Literature Review and Clinical Case Description)
by: Avagimyan Ashot A., et al.
Published: (2019-12-01)

Irisin/FNDC5 Regulates Endothelial Function to Improve Post‐Stroke‐Induced Cognitive Dysfunction by Stimulating AMPK‐eNOS Signaling
by: Hui‐Hui Guo, et al.
Published: (2025-09-01)

Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice
by: Hangzhuo Li, et al.
Published: (2021-06-01)

Comparative Genomic Characterization of Buffalo Fibronectin Type III Domain Proteins: Exploring the Novel Role of FNDC5/Irisin as a Ligand of Gonadal Receptors
by: Siwen Wu, et al.
Published: (2021-11-01)

Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway
by: Anurag Kumar Gautam, et al.
Published: (2022-01-01)

Molecular perspectives on systemic priming and concomitant immunity in colorectal carcinoma
by: Suman Kumar Ray, et al.
Published: (2024-03-01)

The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice
by: Eunhee Cho, et al.
Published: (2021-02-01)

Irisin Ameliorate Acute Pancreatitis and Acinar Cell Viability through Modulation of the Unfolded Protein Response (UPR) and PPARγ-PGC1α-FNDC5 Pathways
by: Avital Horwitz, et al.
Published: (2024-05-01)

Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice
by: Chaeeun Cho, et al.
Published: (2023-04-01)

Chemotherapeutic Interventions Against Tuberculosis
by: Neeraj Shakya, et al.
Published: (2012-06-01)

Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Patients Undergoing Treatment with Cardiotoxic Chemotherapeutic Agents
by: Ömer Kertmen, et al.
Published: (2024-09-01)

Gene Location, Expression, and Function of FNDC5 in Meishan Pigs
by: Chunbo Cai, et al.
Published: (2017-08-01)

Irisin suppressed the progression of TBI via modulating AMPK/MerTK/autophagy and SYK/ROS/inflammatory signaling
by: Kuo Zhang, et al.
Published: (2025-05-01)

WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis
by: Panpan Tai, et al.
Published: (2023-11-01)

Role of chemotherapeutic drugs in immunomodulation of cancer
by: Oishi Mukherjee, et al.
Published: (2023-01-01)

The efficacy of VAC therapy on chemotherapeutic extravasation ulcers: An experimental study
by: Vinay Kumar Tiwari
Published: (2014-09-01)

Investigation of rs1746661 Polymorphism in FNDC5 Gene in Obese Patients
by: Elham Hadi, et al.
Published: (2024-12-01)