Modulating Myofibroblastic Differentiation of Fibroblasts through Actin-MRTF Signaling Axis by Micropatterned Surfaces for Suppressed Implant-Induced Fibrosis
Myofibroblasts, the primary effector cells for implant-induced fibrosis, contribute to this process by secreting excessive collagen-rich matrix and contracting. Thus, approaches that suppress myofibroblasts may achieve desirable suppression effects in the fibrotic process. As one of the important ph...
| Published in: | Research |
|---|---|
| Main Authors: | Weiju Han, Qi Chu, Junliang Li, Zixuan Dong, Xuetao Shi, Xiaoling Fu |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2023-01-01
|
| Online Access: | https://spj.science.org/doi/10.34133/research.0049 |
Similar Items
Role of CRP2-MRTF interaction in functions of myofibroblasts
by: Ken’ichiro Hayashi, et al.
Published: (2023-05-01)
by: Ken’ichiro Hayashi, et al.
Published: (2023-05-01)
Regulation of actin cytoskeleton via photolithographic micropatterning
by: Fulin Xing, et al.
Published: (2023-03-01)
by: Fulin Xing, et al.
Published: (2023-03-01)
ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis
by: Aiwen Jiang, et al.
Published: (2025-12-01)
by: Aiwen Jiang, et al.
Published: (2025-12-01)
Regulation of myofibroblast dedifferentiation in pulmonary fibrosis
by: Xuetao Ju, et al.
Published: (2024-07-01)
by: Xuetao Ju, et al.
Published: (2024-07-01)
Immunohistochemical evaluation of myofibroblasts using alpha-smooth muscle actin in oral submucous fibrosis
by: Teena Philip, et al.
Published: (2014-01-01)
by: Teena Philip, et al.
Published: (2014-01-01)
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
by: Sergi Marco, et al.
Published: (2021-11-01)
by: Sergi Marco, et al.
Published: (2021-11-01)
Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis
by: Junaid Afzal, et al.
Published: (2022-09-01)
by: Junaid Afzal, et al.
Published: (2022-09-01)
The nature and intensity of mechanical stimulation drive different dynamics of MRTF-A nuclear redistribution after actin remodeling in myoblasts.
by: Lorraine Montel, et al.
Published: (2019-01-01)
by: Lorraine Montel, et al.
Published: (2019-01-01)
The Rho/MRTF-pirin axis: a promising target for overcoming melanoma drug resistance
by: Xiaoyan Chen, et al.
Published: (2025-07-01)
by: Xiaoyan Chen, et al.
Published: (2025-07-01)
The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition
by: Qianyi Bao, et al.
Published: (2024-04-01)
by: Qianyi Bao, et al.
Published: (2024-04-01)
Cavin‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis
by: Yusuke Higuchi, et al.
Published: (2024-02-01)
by: Yusuke Higuchi, et al.
Published: (2024-02-01)
Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction
by: Nina Noskovicova, et al.
Published: (2021-07-01)
by: Nina Noskovicova, et al.
Published: (2021-07-01)
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis.
by: Xu Shiwen, et al.
Published: (2015-01-01)
by: Xu Shiwen, et al.
Published: (2015-01-01)
MRTF specifies a muscle-like contractile module in Porifera
by: J. Colgren, et al.
Published: (2022-07-01)
by: J. Colgren, et al.
Published: (2022-07-01)
Fibroblasts and myofibroblasts in wound healing
by: Darby IA, et al.
Published: (2014-11-01)
by: Darby IA, et al.
Published: (2014-11-01)
Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion
by: Satoya Yoshida, et al.
Published: (2024-09-01)
by: Satoya Yoshida, et al.
Published: (2024-09-01)
Trigonelline hydrochloride attenuates silica-induced pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
by: Fengqin Zhang, et al.
Published: (2024-06-01)
by: Fengqin Zhang, et al.
Published: (2024-06-01)
Gene regulation and deregulation by MAL/MRTF coactivators
by: Posern G
Published: (2009-02-01)
by: Posern G
Published: (2009-02-01)
Modulation of human dermal microvascular endothelial cell and human gingival fibroblast behavior by micropatterned silica coating surfaces for zirconia dental implant applications
by: Marta S Laranjeira, et al.
Published: (2014-03-01)
by: Marta S Laranjeira, et al.
Published: (2014-03-01)
WCN25-1565 Dietary Interventions Modulate Immune Metabolism and Fibroblast-to-Myofibroblast Conversion to Attenuate Renal Fibrosis
by: Saurabh Chaturvedi, et al.
Published: (2025-02-01)
by: Saurabh Chaturvedi, et al.
Published: (2025-02-01)
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition
by: Li Xu, et al.
Published: (2023-11-01)
by: Li Xu, et al.
Published: (2023-11-01)
In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis
by: Aristides D. Tagalakis, et al.
Published: (2018-11-01)
by: Aristides D. Tagalakis, et al.
Published: (2018-11-01)
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
by: Chenxi Zeng, et al.
Published: (2024-10-01)
by: Chenxi Zeng, et al.
Published: (2024-10-01)
Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis
by: Wenqiang Yu, et al.
Published: (2024-12-01)
by: Wenqiang Yu, et al.
Published: (2024-12-01)
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction
by: Harikrishnan Venugopal, et al.
Published: (2022-04-01)
by: Harikrishnan Venugopal, et al.
Published: (2022-04-01)
Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts
by: Amisha Sanghani, et al.
Published: (2021-03-01)
by: Amisha Sanghani, et al.
Published: (2021-03-01)
Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?
by: Elena Ortiz-Zapater, et al.
Published: (2022-06-01)
by: Elena Ortiz-Zapater, et al.
Published: (2022-06-01)
Editorial: Pulmonary fibrosis and lung carcinogenesis: do myofibroblasts and cancer-associated fibroblasts share a common identity?
by: Daniela de Totero, et al.
Published: (2024-03-01)
by: Daniela de Totero, et al.
Published: (2024-03-01)
Correction to: Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
by: Peng Liu, et al.
Published: (2023-04-01)
by: Peng Liu, et al.
Published: (2023-04-01)
Myofibroblasts in Schistosomal Portal Fibrosis of Man
by: Andrade Zilton A, et al.
Published: (1999-01-01)
by: Andrade Zilton A, et al.
Published: (1999-01-01)
Redox Mechanisms Driving Skin Fibroblast-to-Myofibroblast Differentiation
by: Marzieh Aminzadehanboohi, et al.
Published: (2025-04-01)
by: Marzieh Aminzadehanboohi, et al.
Published: (2025-04-01)
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay
by: Elisabeth Bäck, et al.
Published: (2025-04-01)
by: Elisabeth Bäck, et al.
Published: (2025-04-01)
Sialylation regulates myofibroblast differentiation of human skin fibroblasts
by: Norihiko Sasaki, et al.
Published: (2017-04-01)
by: Norihiko Sasaki, et al.
Published: (2017-04-01)
Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation
by: Yiling Han, et al.
Published: (2025-01-01)
by: Yiling Han, et al.
Published: (2025-01-01)
Recreating the Trabecular Outflow Tissue on Implantable, Micropatterned, Ultrathin, Porous Polycaprolactone Scaffolds
by: Luke A. Beardslee, et al.
Published: (2023-06-01)
by: Luke A. Beardslee, et al.
Published: (2023-06-01)
Identification of novel inhibitors of the transcriptional coactivator MRTF-A for HCC therapy
by: Miriam Jasmin Franz, et al.
Published: (2024-09-01)
by: Miriam Jasmin Franz, et al.
Published: (2024-09-01)
Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
by: Pankaj Patyal, et al.
Published: (2024-02-01)
by: Pankaj Patyal, et al.
Published: (2024-02-01)
Fibroblast Growth Factor-1 Suppresses TGF-β-Mediated Myofibroblastic Differentiation of Rat Hepatic Stellate Cells
by: Eva Peterová, et al.
Published: (2017-02-01)
by: Eva Peterová, et al.
Published: (2017-02-01)
Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation
by: Guangrui Chen, et al.
Published: (2023-01-01)
by: Guangrui Chen, et al.
Published: (2023-01-01)
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages
by: Chengju Luo, et al.
Published: (2025-04-01)
by: Chengju Luo, et al.
Published: (2025-04-01)
Similar Items
-
Role of CRP2-MRTF interaction in functions of myofibroblasts
by: Ken’ichiro Hayashi, et al.
Published: (2023-05-01) -
Regulation of actin cytoskeleton via photolithographic micropatterning
by: Fulin Xing, et al.
Published: (2023-03-01) -
ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis
by: Aiwen Jiang, et al.
Published: (2025-12-01) -
Regulation of myofibroblast dedifferentiation in pulmonary fibrosis
by: Xuetao Ju, et al.
Published: (2024-07-01) -
Immunohistochemical evaluation of myofibroblasts using alpha-smooth muscle actin in oral submucous fibrosis
by: Teena Philip, et al.
Published: (2014-01-01)
