The dispensability of VH-VL pairing and the indispensability of VL domain integrity in the IgG1 secretion process

Introduction: The CH1 domain of IgG antibodies controls assembly and secretion, mediated by the molecular chaperone BiP via the endoplasmic reticulum protein quality control (ERQC) mechanism. However, it is not clear whether the variable domains are necessary for this process.Methods: Here, we gener...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Juho Choi, Yerin Jeon, Youngin Roh, Jeongyun Jang, Eunbin Lee, Luigie Villamante, Minjae Kim, Myung-Hee Kwon
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	IgG assembly secretion endoplasmic reticulum quality control VH domain VL domain
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1346259/full