MOF-Mediated Aloe-Emodin Delivery Enhances Hepatocellular Carcinoma Immunotherapy via Pyroptosis and Immunosuppressant Synergy

Huaying Xie,&ast; Xiaoyuan Yi,&ast; Kunzhao Huang, Jianzhang Luo, Qingyu Zeng, Feifei He, Liyan Wang Digestive Department, Affiliated Hospital of Guilin Medical University, Guilin, 541001, People’s Republic of China&ast;These authors contributed equally to this workCorrespond...

Full description

Bibliographic Details
Published in:	International Journal of Nanomedicine
Main Authors:	Xie H, Yi X, Huang K, Luo J, Zeng Q, He F, Wang L
Format:	Article
Language:	English
Published:	Dove Medical Press 2025-09-01
Subjects:	Aloe-Emodin Microenvironment response Pyroptosis Immunosuppressor BMS-202
Online Access:	https://www.dovepress.com/mof-mediated-aloe-emodin-delivery-enhances-hepatocellular-carcinoma-im-peer-reviewed-fulltext-article-IJN

Similar Items

Aloe-Emodin Derivative, an Anthraquinone Compound, Attenuates Pyroptosis by Targeting NLRP3 Inflammasome in Diabetic Cardiomyopathy
by: Yingying Hu, et al.
Published: (2023-09-01)

Potential preventative impact of aloe-emodin nanoparticles on cerebral stroke-associated myocardial injury by targeting myeloperoxidase: In supporting with In silico and In vivo studies
by: Praveen Kumar Pasala, et al.
Published: (2024-06-01)

Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
by: Aysenur Gunaydin-Akyildiz, et al.
Published: (2023-07-01)

The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents
by: Hai Shang, et al.
Published: (2022-09-01)

Neuroprotection of Emodin by Inhibition of Microglial NLRP3 Inflammasome-Mediated Pyroptosis
by: Wen Jiang, et al.
Published: (2023-03-01)

Peptide-Mediated Targeted Delivery of Aloe-Emodin as Anticancer Drug
by: Annarita Stringaro, et al.
Published: (2022-07-01)

Prediction of potential targets of aloe-emodin in the treatment of hepatocellular carcinoma using network pharmacology combined with bioinformatics
by: Jinlong Wei, et al.
Published: (2025-04-01)

The examination of in vitro photosensitizing efficacy of aloe-emodin loaded liposome following photodynamic therapy on melanoma cell lines
by: Martyna Nowak-Perlak, et al.
Published: (2025-08-01)

Inhibitory Mechanism of Aloe Emodin on α-Glucosidase and Synergistic Effect with Acarbose
by: QIN Chaofeng, LI Jiao, HAO Jingwen, BU Yaqin, LI Sheng, CHEN Naidong
Published: (2024-04-01)

Response Surface Methodology (RSM)-Based Optimization of Ultrasound-Assisted Extraction of Sennoside A, Sennoside B, Aloe-Emodin, Emodin, and Chrysophanol from <i>Senna alexandrina</i> (Aerial Parts): HPLC-UV and Antioxidant Analysis
by: Perwez Alam, et al.
Published: (2022-01-01)

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity
by: Weilian Bao, et al.
Published: (2024-09-01)

Sensitization of Non-Small Cell Lung Cancer Cells to Gefitinib and Reversal of Epithelial–Mesenchymal Transition by Aloe-Emodin Via PI3K/Akt/TWIS1 Signal Blockage
by: Minghui Peng, et al.
Published: (2022-05-01)

Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats
by: Guofang Zhang, et al.
Published: (2025-06-01)

Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments
by: Mingyang Zhu, et al.
Published: (2023-10-01)

Emodin alleviates lung ischemia–reperfusion injury by suppressing gasdermin D‐mediated pyroptosis in rats
by: Tao Jin, et al.
Published: (2023-03-01)

Aloe-Emodin activated by Photodynamic therapy and diode laser on carious affected dentin and survival of S. mutans. An-invitro SEM assessment
by: Basil Almutairi
Published: (2025-06-01)

Aloe Emodin Alleviates Radiation‐Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
by: Fan Ouyang, et al.
Published: (2024-12-01)

Aloe-emodin plus TIENAM ameliorate cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating microbiota
by: Jingqian Su, et al.
Published: (2024-12-01)

Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study
by: Talib Hussain, et al.
Published: (2024-01-01)

Aloe-emodin attenuates hyperuricemia-induced renal injury in mice by mitigating inflammation and oxidative stress
by: Shengfeng Wang, et al.
Published: (2025-10-01)

Aloe-Emodin Relieves High-Fat Diet Induced QT Prolongation via MiR-1 Inhibition and IK1 Up-Regulation in Rats
by: Yan Bai, et al.
Published: (2017-10-01)

Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway
by: Yizhuo Luo, et al.
Published: (2023-07-01)

Aloe-emodin alleviates inflammatory bowel disease in mice by modulating intestinal microbiome homeostasis via the IL-4/IL-13 axis
by: Dong Yang, et al.
Published: (2024-08-01)

Temperature and pH Stability of Anthraquinones from Native <i>Aloe vera</i> Gel, Spray-Dried and Freeze-Dried <i>Aloe vera</i> Powders during Storage
by: Uzma Sadiq, et al.
Published: (2022-05-01)

Aloe-Emodin Overcomes Anti-Cancer Drug Resistance to Temozolomide and Prevents Colony Formation and Migration in Primary Human Glioblastoma Cell Lines NULU and ZAR
by: Sabrina Staffieri, et al.
Published: (2023-08-01)

Canal disinfectants: Potassium titanyl phosphate laser, magnesium oxide nanoparticles, and aloe-emodin PDT on smear layer removal and bond strength of glass fiber post to root dentin
by: Mai Mohammed Alhamdan
Published: (2025-06-01)

Simultaneous Estimation of Rhein and Aloe-Emodin in Traditional and Ultrasound-Based Extracts of <i>Rheum palmatum</i> L. (Rhubarb) Using Sustainable Reverse-Phase and Conventional Normal-Phase HPTLC Methods
by: Mohammed H. Alqarni, et al.
Published: (2022-05-01)

Anticancer effects of aloe-emodin from Rheum undulatum L. through activation of the p53 pathway in human prostate cancer cells
by: Nguyen Khoi Song Tran, et al.
Published: (2024-12-01)

Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy
by: Dehao Du, et al.
Published: (2025-06-01)

The potency of aloe emodin‐loaded nanoparticles in conjunction with IFN‐γ for the pretreatment of mesenchymal stem cells with class II transactivator silence to alleviate severe acute pancreatitis
by: Yu Zou, et al.
Published: (2025-03-01)

Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis
by: Xiong Liu, et al.
Published: (2025-08-01)

Combination of aloe emodin, emodin, and rhein from Aloe with EDTA sensitizes the resistant Acinetobacter baumannii to polymyxins
by: Yue Zhao, et al.
Published: (2024-09-01)

Bone marrow mesenchymal stem cell‐derived exosomes miR‐202‐5p inhibited pyroptosis to alleviate lung ischemic‐reperfusion injury by targeting CMPK2
by: Zhi‐Lu Sun, et al.
Published: (2023-07-01)

Emodin as an Inhibitor of PRV Infection In Vitro and In Vivo
by: Xiaojing Cai, et al.
Published: (2023-09-01)

Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63
by: Monika Horvat, et al.
Published: (2021-11-01)

BMS‐202, a PD‐1/PD‐L1 inhibitor, decelerates the pro‑fibrotic effects of fibroblasts derived from scar tissues via ERK and TGFβ1/Smad signaling pathways
by: Yuanyuan Cai, et al.
Published: (2022-10-01)

Determination of 16 Hydroxyanthracene Derivatives in Food Supplements Using LC-MS/MS: Method Development and Application
by: Svetlana V. Malysheva, et al.
Published: (2024-11-01)

Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome
by: Levi Evans, et al.
Published: (2023-08-01)

Emodin in cardiovascular disease: The role and therapeutic potential
by: Yuanyuan Guo, et al.
Published: (2022-12-01)

Emodin attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis
by: Yue-Ran Cui, et al.
Published: (2023-01-01)