Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases
Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability. To expand the repertoire of Ad vectors for receptor usage an...
| Published in: | Viruses |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/8/1493 |
| _version_ | 1850109235633848320 |
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| author | Marwa Alhashimi Ahmed Elkashif Ekramy E. Sayedahmed Suresh K. Mittal |
| author_facet | Marwa Alhashimi Ahmed Elkashif Ekramy E. Sayedahmed Suresh K. Mittal |
| author_sort | Marwa Alhashimi |
| collection | DOAJ |
| container_title | Viruses |
| description | Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability. To expand the repertoire of Ad vectors for receptor usage and circumvention of Ad vector immunity, the use of less prevalent human Ad types or nonhuman Ads were explored for vector design. Notably, many nonhuman Ad vectors have shown great promise in preclinical and clinical studies as vectors for vaccine delivery. This review describes the key features of several nonhuman Ad vector platforms and their implications in developing effective vaccines against infectious diseases. |
| format | Article |
| id | doaj-art-2facb3dfcd9d4b548d151f6f3a376b18 |
| institution | Directory of Open Access Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-2facb3dfcd9d4b548d151f6f3a376b182025-08-20T00:00:48ZengMDPI AGViruses1999-49152021-07-01138149310.3390/v13081493Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious DiseasesMarwa Alhashimi0Ahmed Elkashif1Ekramy E. Sayedahmed2Suresh K. Mittal3Immunology and Infectious Disease, and Purdue University Center for Cancer Research, Department of Comparative Pathobiology, Purdue Institute for Inflammation, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USAImmunology and Infectious Disease, and Purdue University Center for Cancer Research, Department of Comparative Pathobiology, Purdue Institute for Inflammation, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USAImmunology and Infectious Disease, and Purdue University Center for Cancer Research, Department of Comparative Pathobiology, Purdue Institute for Inflammation, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USAImmunology and Infectious Disease, and Purdue University Center for Cancer Research, Department of Comparative Pathobiology, Purdue Institute for Inflammation, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USASeveral human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability. To expand the repertoire of Ad vectors for receptor usage and circumvention of Ad vector immunity, the use of less prevalent human Ad types or nonhuman Ads were explored for vector design. Notably, many nonhuman Ad vectors have shown great promise in preclinical and clinical studies as vectors for vaccine delivery. This review describes the key features of several nonhuman Ad vector platforms and their implications in developing effective vaccines against infectious diseases.https://www.mdpi.com/1999-4915/13/8/1493adenoviral vectornonhuman adenoviral vectorviral vectorvaccineinfectious disease |
| spellingShingle | Marwa Alhashimi Ahmed Elkashif Ekramy E. Sayedahmed Suresh K. Mittal Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases adenoviral vector nonhuman adenoviral vector viral vector vaccine infectious disease |
| title | Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases |
| title_full | Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases |
| title_fullStr | Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases |
| title_full_unstemmed | Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases |
| title_short | Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases |
| title_sort | nonhuman adenoviral vector based platforms and their utility in designing next generation of vaccines for infectious diseases |
| topic | adenoviral vector nonhuman adenoviral vector viral vector vaccine infectious disease |
| url | https://www.mdpi.com/1999-4915/13/8/1493 |
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