Comparison of the Efficacy of Tazarotene 0.1% Cream Versus Clindamycin 1% Gel in the Treatment of Acne Vulgaris

• الحاوية / القاعدة: Pakistan Armed Forces Medical Journal
• المؤلفون الرئيسيون: Afnan Bin Haq, Zafar Iqbal Shaikh, Sadia Malik, Amir Ashraf, Syed Sajid Ali Shah, Ayesha Anwar
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: Army Medical College Rawalpindi 2022-11-01
• الموضوعات: Acne vulgaris; Clindamycin; Dermatology; GAGS score; Tazarotene
• الوصول للمادة أونلاين: https://www.pafmj.org/index.php/PAFMJ/article/view/6764
• تدمد: 0030-9648; 2411-8842

Objective: To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating acne vulgaris. Study Design: Quasi-experimental study. Place and Duration of the Study: Dermatology Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jul 2018. Methodology: One hundred and fifty-four patients of both genders who had moderate acne vulgaris for more than four weeks were divided into two Groups. In both Groups, patients applied one-fourth fingertip unit of Tazarotene 0.1% cream in the evening once daily and Clindamycin 1% gel over the affected area in the morning once daily for 12 weeks. The Global Acne Grading System Score (GAGS score) was used for severity and efficacy assessment. Results: The majority of the patients belonged to 13-25 years of age, i.e., 61(79.2%) and 54(70.1%) in Group-A (Tazarotene 0.1% cream) and Group-B (Clindamycin 1% gel), respectively. The efficacy of topical Tazarotene cream (0.1%) was better than topical Clindamycin 1% gel, and the difference was statistically significant with a p-value less than 0.01. GAGS score <10 was observed in 54.5% and 33.8% of patients in Group-A and Group-B, respectively. Conclusion: Topical Tazarotene cream (0.1%) was more effective than topical Clindamycin 1% gel in treating acne vulgaris.