Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma
Post-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation,...
| Published in: | Biomolecules |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-07-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/8/908 |
| _version_ | 1849856843603509248 |
|---|---|
| author | Xinyu Zhou Sirui Hang Qingqing Wang Liu Xu Peter Wang |
| author_facet | Xinyu Zhou Sirui Hang Qingqing Wang Liu Xu Peter Wang |
| author_sort | Xinyu Zhou |
| collection | DOAJ |
| container_title | Biomolecules |
| description | Post-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, and nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development and progression, especially in hepatocellular carcinoma (HCC). This review outlines the role of O-GlcNAcylation in the development and progression of HCC. Moreover, we delve into the underlying mechanisms of O-GlcNAcylation in HCC and highlight compounds that target O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) to improve treatment outcomes. Understanding the role of O-GlcNAcylation in HCC will offer insights into potential therapeutic strategies targeting OGT and OGA, which could improve treatment for patients with HCC. |
| format | Article |
| id | doaj-art-30de686b95fa48c19b1d3041a1b69bc2 |
| institution | Directory of Open Access Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-30de686b95fa48c19b1d3041a1b69bc22025-08-20T01:21:32ZengMDPI AGBiomolecules2218-273X2024-07-0114890810.3390/biom14080908Decoding the Role of O-GlcNAcylation in Hepatocellular CarcinomaXinyu Zhou0Sirui Hang1Qingqing Wang2Liu Xu3Peter Wang4Department of Surgery, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaDepartment of Surgery, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaDepartment of Hepatobiliary Surgery, The First Hospital of Jiaxing, Jiaxing 314051, ChinaDepartment of Hepatobiliary Surgery, The First Hospital of Jiaxing, Jiaxing 314051, ChinaDepartment of Medicine, Zhejiang Zhongwei Medical Research Center, Hangzhou 310000, ChinaPost-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, and nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development and progression, especially in hepatocellular carcinoma (HCC). This review outlines the role of O-GlcNAcylation in the development and progression of HCC. Moreover, we delve into the underlying mechanisms of O-GlcNAcylation in HCC and highlight compounds that target O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) to improve treatment outcomes. Understanding the role of O-GlcNAcylation in HCC will offer insights into potential therapeutic strategies targeting OGT and OGA, which could improve treatment for patients with HCC.https://www.mdpi.com/2218-273X/14/8/908OGAOGTHCCO-GlcNAcylationproliferationimmunotherapy |
| spellingShingle | Xinyu Zhou Sirui Hang Qingqing Wang Liu Xu Peter Wang Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma OGA OGT HCC O-GlcNAcylation proliferation immunotherapy |
| title | Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma |
| title_full | Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma |
| title_fullStr | Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma |
| title_full_unstemmed | Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma |
| title_short | Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma |
| title_sort | decoding the role of o glcnacylation in hepatocellular carcinoma |
| topic | OGA OGT HCC O-GlcNAcylation proliferation immunotherapy |
| url | https://www.mdpi.com/2218-273X/14/8/908 |
| work_keys_str_mv | AT xinyuzhou decodingtheroleofoglcnacylationinhepatocellularcarcinoma AT siruihang decodingtheroleofoglcnacylationinhepatocellularcarcinoma AT qingqingwang decodingtheroleofoglcnacylationinhepatocellularcarcinoma AT liuxu decodingtheroleofoglcnacylationinhepatocellularcarcinoma AT peterwang decodingtheroleofoglcnacylationinhepatocellularcarcinoma |