Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical in Leigh Syndrome (LS), a common MD presentation, leading to motor and respiratory deficits, seizures and premature death. However,...

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Bibliographic Details
Published in:	eLife
Main Authors:	Irene Bolea, Alejandro Gella, Elisenda Sanz, Patricia Prada-Dacasa, Fabien Menardy, Angela M Bard, Pablo Machuca-Márquez, Abel Eraso-Pichot, Guillem Mòdol-Caballero, Xavier Navarro, Franck Kalume, Albert Quintana
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-08-01
Subjects:	mitochondrial disease mouse genetics neuropathology cell type-specific
Online Access:	https://elifesciences.org/articles/47163

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