The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.

During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1. Ogg1 and Nth1 excise oxidized bases, and nick the resulting ab...

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Bibliographic Details
Published in:	PLoS ONE
Main Authors:	Anna J Ucher, Erin K Linehan, George W Teebor, Carol E Schrader, Janet Stavnezer
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3334981?pdf=render

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