Overexpression of Mitochondrial Ferritin Enhances Blood–Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells

Blood–brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following cerebral ischemia reperfusion (I/R) injury can disru...

Full description

Bibliographic Details
Published in:	Antioxidants
Main Authors:	Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	blood–brain barrier ischemic stroke mitochondrial ferritin iron endothelial cells
Online Access:	https://www.mdpi.com/2076-3921/11/7/1257

Similar Items

Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion
by: Peina Wang, et al.
Published: (2022-11-01)

Mitochondrial Ferritin: Its Role in Physiological and Pathological Conditions
by: Sonia Levi, et al.
Published: (2021-08-01)

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis
by: Yue-Qi Wang, et al.
Published: (2016-12-01)

Serum ferritin level as a severity marker in patients with ischemic stroke using modified Rankin scale
by: Santhosh B T, et al.
Published: (2023-07-01)

Endothelial mitochondrial homeostasis in the development and progression of atherosclerosis
by: Naznin Sultana Remex, et al.
Published: (2026-06-01)

Serum ferritin is associated with the presence of ischemic stroke among individuals with type 2 diabetes
by: Youyou Zhang, et al.
Published: (2024-03-01)

Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments
by: Didi He, et al.
Published: (2016-08-01)

Mitochondrial Iron Transport and Homeostasis in Plants
by: Anshika eJain, et al.
Published: (2013-09-01)

Recombinant Human Heavy Chain Ferritin Nanoparticles Serve as ROS Scavengers for the Treatment of Ischemic Stroke
by: Qi M, et al.
Published: (2024-03-01)

Treatment of low serum ferritin in females with alopecia by oral iron.
by: Wisam Ali Ameen, et al.
Published: (2015-01-01)

Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila
by: Zhixin Ma, et al.
Published: (2024-09-01)

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration
by: Barry B. Muhoberac, et al.
Published: (2019-12-01)

Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
by: Xing Chang, et al.
Published: (2024-09-01)

Iron Homeostasis-Related Parameters and Hepcidin/Ferritin Ratio: Emerging Sex-Specific Predictive Markers for Metabolic Syndrome
by: Baraah T. Abu AlSel, et al.
Published: (2024-08-01)

LARP7 overexpression alleviates neuronal injury after ischemic stroke by promoting endothelial cell autophagy
by: Lili Shao, et al.
Published: (2026-06-01)

Changes of Hepcidin, Ferritin and Iron Levels in Cycling Purebred Spanish Mares
by: Katiuska Satué, et al.
Published: (2023-03-01)

Comparative intrafollicular and plasma iron, ferritin, and transferrin concentrations in cycling mares
by: Katiuska Satué, et al.
Published: (2024-10-01)

Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions
by: Ana C. Moreira, et al.
Published: (2020-04-01)

Associations of Ultrasound Findings with Serum Iron and Ferritin Levels in Children with Obesity
by: Mioara Desdemona Stepan, et al.
Published: (2024-04-01)

Ability of serum ferritin to diagnose iron deficiency anemia in an elderly cohort
by: Mansour Babaei, et al.

Evaluation and association of serum iron and ferritin levels in children with dental caries
by: N S Venkatesh Babu, et al.
Published: (2017-01-01)

Iron and Ferritin Levels of Children and Adolescents with Attention Deficit Hyperactivity Disorder and Attention Deficit Hyperactivity Disorder-Not Otherwise Specified
by: Yusuf Öztürk, et al.
Published: (2020-09-01)

Biomimetic ferritin nanocages for synergistic co-delivery of metformin and rapamycin restore neurodevelopmental homeostasis in autism spectrum disorders
by: Yizhe Shen, et al.
Published: (2025-10-01)

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
by: Lei Liu, et al.
Published: (2023-10-01)

Tissue Iron in Friedreich Ataxia
by: Arnulf H Koeppen
Published: (2024-01-01)

Ferritin-mediated regulation of gut microbiota homeostasis promotes blood-feeding adaptation in the tick Haemaphysalis doenitzi
by: Zhihua Gao, et al.
Published: (2025-11-01)

The protective role of endothelial GLUT1 in ischemic stroke
by: Qiwei Peng, et al.
Published: (2024-05-01)

Serum Ferritin Levels in Pregnancy
by: Cengiz Demir, et al.
Published: (2011-03-01)

Mitochondrial homeostasis is maintained in the absence of autophagy
by: Christina G. Towers
Published: (2021-09-01)

Distinguishing Non-Arteritic Ischemic Optic Neuropathy from optic Neuritis with Serum Vitamin B12, Ferritin and Folic Acid Level
by: Hande Guclu, et al.
Published: (2018-08-01)

Vector-induced ferritin overexpression limits cell motility by controlling cell stiffness in glioblastoma cells
by: Joan N. Whittier, et al.
Published: (2026-06-01)

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives
by: Shuchen Meng, et al.
Published: (2025-09-01)

Structural characteristics, multifunctional applications, and research prospects of ferritin: a case study of sturgeon ferritin
by: Nida Maqsood, et al.
Published: (2025-07-01)

Ferritin adsorption onto chrysotile asbestos fibers influences the protein secondary structure
by: Martina Zangari, et al.
Published: (2024-10-01)

Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels
by: Tae-Joon Kim, et al.
Published: (2018-12-01)

Characterization Analysis of Human Anti-Ferritin Autoantibodies
by: Shusaku Higashi, et al.
Published: (2014-03-01)

Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker
by: Katarzyna Szymulewska-Konopko, et al.
Published: (2025-01-01)

Hepcidin-to-Ferritin Ratio Is Decreased in Astrocytes With Extracellular Alpha-Synuclein and Iron Exposure
by: Juntao Cui, et al.
Published: (2020-03-01)

An Overview of Heavy Chain Ferritin in Cancer
by: Xiaoyan Shi, et al.
Published: (2023-08-01)

The Interplay of Exogenous and Endogenous Hydrogen Sulfide (H<sub>2</sub>S) in Maintaining Redox Homeostasis in Individuals with Low Ferritin Levels
by: Zaid Altaany, et al.
Published: (2023-05-01)