Prophylactic and Therapeutic Efficacies of Ingavirin®, a Novel Russian Chemotherapeutic, with Respect to Influenza Pathogen A (H5N1)

The experimental study of the Ingavirin® efficacy against the influenza virus A (H5N1) on intranasally-infected albino mice vs. Tamiflue® and Arbidol® showed that when used for the prophylaxis, urgent prophylaxis and therapy it was effective in the protec-tiom of the animals from death. The efficien...

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Bibliographic Details
Published in:Антибиотики и Химиотерапия
Main Authors: S. YA. Loginova, S. V. Borisevich, O. M. Shklyaeva, V. A. Maksimov, V. P. Bondarev, V. E. Nebolsin
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Subjects:
influenza virus a (h5n1)
ingavirin®
antiviral efficacy
prophylaxis
urgent prophylaxis
therapy
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/315
Description
Summary:The experimental study of the Ingavirin® efficacy against the influenza virus A (H5N1) on intranasally-infected albino mice vs. Tamiflue® and Arbidol® showed that when used for the prophylaxis, urgent prophylaxis and therapy it was effective in the protec-tiom of the animals from death. The efficient dose for the prophylaxis of the influenza infection was 5 mg/kg (protective efficacy of 46.7%) and for the urgent prophylaxis and therapy it was 15 mg/kg (protective efficacy of 40.0 and 35.0% respectively).
ISSN:0235-2990

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