Collapsing Focal Segmental Glomerulosclerosis and Acute Kidney Injury Associated With Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: A Case Report

Chimeric antigen receptor T (CAR-T) cell treatment is a rapidly emerging therapy for relapsed/refractory hematologic malignancies. Although cytokine release syndrome is a common complication, a concomitant development of biopsy-proven collapsing glomerulopathy and acute kidney injury (AKI) has not b...

Full description

Bibliographic Details
Published in:	Kidney Medicine
Main Authors:	Ratna Acharya, Biljana Horn, Xu Zeng, Kiran Upadhyay
Format:	Article
Language:	English
Published:	Elsevier 2021-11-01
Subjects:	Chimeric antigen receptor T cells collapsing FSGS cytokine release syndrome acute kidney injury leukemia
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590059521001710

Similar Items

Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
by: Hanfei Guo, et al.
Published: (2022-03-01)

Collapsing Focal Segmental Glomerulosclerosis in Siblings With Compound Heterozygous Variants in NUP93 Expand the Spectrum of Kidney Phenotypes Associated With Nucleoporin Gene Mutations
by: Rachel K. Cason, et al.
Published: (2022-07-01)

Advances on chimeric antigen receptor-modified T-cell therapy for oncotherapy
by: Yanyu Pang, et al.
Published: (2018-05-01)

A Review of Focal Segmental Glomerulosclerosis Classification With a Focus on Genetic Associations
by: Marco Bonilla, et al.
Published: (2024-06-01)

Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis
by: Natasha de Zoysa, et al.
Published: (2024-03-01)

Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study
by: Jing Yang, et al.
Published: (2025-01-01)

Focal Segmental Glomerulosclerosis and Recurrence in Living Donor Recipients
by: Mang J, et al.
Published: (2021-07-01)

Cytopenia after chimeric antigen receptor T cell immunotherapy in relapsed or refractory lymphoma
by: Jin Zhou, et al.
Published: (2022-09-01)

Cardiovascular toxicities associated with chimeric antigen receptor T-cell therapy
by: Jia-Hui Liu, et al.
Published: (2025-05-01)

A new index for the outcome of focal segmental glomerulosclerosis
by: Liu Chan, et al.
Published: (2024-04-01)

Clopidogrel for Proteinuria Reduction in Focal Segmental Glomerulosclerosis: Phase 2 Trial Design
by: Lisa Daniel-Fischer, et al.
Published: (2024-02-01)

Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation
by: Sahra Pajenda, et al.
Published: (2024-07-01)

Procalcitonin level threshold and antibiotic use in patients receiving chimeric antigen receptor T-cell therapy
by: Murari Ramesh, et al.
Published: (2024-12-01)

Improving cell reinfusion to enhance the efficacy of chimeric antigen receptor T-cell therapy and alleviate complications
by: Zhihao Han, et al.
Published: (2024-04-01)

Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
by: Chieh Yang, et al.
Published: (2023-10-01)

Control effect of Dasatinib on the treatment of acute myeloid leukemia and adverse events of CD123 targeting CAR-T: a case report and literature review
by: LI Chunmin, et al.
Published: (2024-02-01)

Mechanisms of antigen-dependent resistance to chimeric antigen receptor (CAR)-T cell therapies
by: Fatemeh Nasiri, et al.
Published: (2025-02-01)

Focal segmental glomerulosclerosis; collapsing variant
by: Peyman Mohammadi Torbati
Published: (2012-07-01)

Improved efficacy with early tocilizumab in the prophylaxis and treatment of cytokine release syndrome of chimeric antigen receptor T cell (CAR-T) therapy for diffuse large B-cell lymphoma than acute lymphoblastic leukemia
by: Chengxin Luan, et al.
Published: (2023-09-01)

Xuebijing enhances antitumor efficacy of anti-CD19 CAR-T cells
by: Jingjing Zhu, et al.
Published: (2024-10-01)

CAR‐T‐OPENIA: Chimeric antigen receptor T‐cell therapy‐associated cytopenias
by: Alankrita Taneja, et al.
Published: (2022-01-01)

Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias
by: Cesar Clavijo Simbaqueba, et al.
Published: (2020-08-01)

Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer
by: Rohtesh S. Mehta, et al.
Published: (2018-02-01)

Focal and Segmental Glomerulosclerosis: A Comprehensive State-of-the-Art Review
by: Dearbhail Ni Cathain, et al.
Published: (2025-07-01)

Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)
by: Eugenio Galli, et al.
Published: (2021-10-01)

Ferroptosis-related genes, a novel therapeutic target for focal segmental glomerulosclerosis
by: Yanbin Lin, et al.
Published: (2024-02-01)

Focal Segmental Glomerulosclerosis caused by Hepatitis B Infection Comorbid with HIV Infection
by: Nicholas Wijayanto, et al.
Published: (2022-09-01)

Chimeric antigen receptor T‐cell therapy: Challenges and framework of outpatient administration
by: Katie S. Gatwood, et al.
Published: (2022-01-01)

A novel malnutrition assessment model predicts the inflammatory storm of relapsed/refractory acute myeloid leukemia following C-type lectin-like molecule-1 chimeric antigen receptor T therapy
by: Tao Zhang, et al.
Published: (2025-07-01)

Chimeric antigen receptor T-cell therapy in the treatment of acute myeloid leukemia: Possible challenges
by: Rahul Jagdishchandra Mittal, et al.
Published: (2021-01-01)

The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
by: Dongfang Liu, et al.
Published: (2020-08-01)

Collapsing focal segmental glomerulosclerosis: Increasing the awareness
by: Muhammed Mubarak
Published: (2012-07-01)

Bioinformatic Analysis Combined With Experimental Validation Reveals Novel Hub Genes and Pathways Associated With Focal Segmental Glomerulosclerosis
by: Yan-Pei Hou, et al.
Published: (2022-01-01)

Nerve Enlargement in Patients with INF2 Variants Causing Peripheral Neuropathy and Focal Segmental Glomerulosclerosis
by: Quynh Tran Thuy Huong, et al.
Published: (2025-01-01)

Chimeric Antigen Receptor (CAR)-T Cell Therapy for Non-Hodgkin’s Lymphoma
by: Maria Giraudo, et al.
Published: (2024-03-01)

Familial Focal Segmental Glomerulosclerosis With Late-Onset Presentation and R229Q/R291W Podocin Mutations
by: Michelle T. P. Riguetti, et al.
Published: (2020-09-01)

NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development
by: Ali Bashiri Dezfouli, et al.
Published: (2021-12-01)

Chimeric Antigen Receptor (CAR) T Cell Therapy for Metastatic Melanoma: Challenges and Road Ahead
by: Tahereh Soltantoyeh, et al.
Published: (2021-06-01)

Chimeric antigen receptors: unleashing a new age of anti-cancer therapy
by: Yan Leyfman
Published: (2018-11-01)

Chimeric antigen receptor natural killer cells: a promising antitumor immunotherapy
by: Yan Wang, et al.
Published: (2023-12-01)