Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice
Microplastics, defined as plastic fragments smaller than 5 mm, degrade from larger pollutants, with nanoscale microplastic particles presenting significant biological interactions. This study investigates the toxic effects of polystyrene nanoplastics (PS-NPs) on juvenile mice, which were exposed thr...
| Published in: | Nanomaterials |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2079-4991/15/1/69 |
| _version_ | 1849559411614285824 |
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| author | Chaoyu Zhou Haiyan Wu Lei Zhang Xiao Xiao Xiaodan Wang Mingju Li Runqiu Cai Jia You Qi Chen Yifei Yang Xinyuan Tian Qianyu Bai Yinzhu Chen Huihui Bao Tianlong Liu |
| author_facet | Chaoyu Zhou Haiyan Wu Lei Zhang Xiao Xiao Xiaodan Wang Mingju Li Runqiu Cai Jia You Qi Chen Yifei Yang Xinyuan Tian Qianyu Bai Yinzhu Chen Huihui Bao Tianlong Liu |
| author_sort | Chaoyu Zhou |
| collection | DOAJ |
| container_title | Nanomaterials |
| description | Microplastics, defined as plastic fragments smaller than 5 mm, degrade from larger pollutants, with nanoscale microplastic particles presenting significant biological interactions. This study investigates the toxic effects of polystyrene nanoplastics (PS-NPs) on juvenile mice, which were exposed through lactation milk and drinking water at concentrations of 0.01 mg/mL, 0.1 mg/mL, and 1 mg/mL. The results show that PS-NP exposure during lactation and juvenile periods caused delayed weight gain and impaired organ development, particularly in the liver and kidneys, without causing functional abnormalities or toxic injuries. The primary toxicity of PS-NPs was observed in the intestinal tract, including shortened villi, disrupted tight junctions, inhibited epithelial cell proliferation, and oxidative stress responses. These findings highlight the importance of evaluating the developmental toxicity of nanoplastics at environmentally relevant doses. |
| format | Article |
| id | doaj-art-389bd4530ebf4e46a2b1949432804eb9 |
| institution | Directory of Open Access Journals |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-389bd4530ebf4e46a2b1949432804eb92025-08-20T02:36:08ZengMDPI AGNanomaterials2079-49912025-01-011516910.3390/nano15010069Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing MiceChaoyu Zhou0Haiyan Wu1Lei Zhang2Xiao Xiao3Xiaodan Wang4Mingju Li5Runqiu Cai6Jia You7Qi Chen8Yifei Yang9Xinyuan Tian10Qianyu Bai11Yinzhu Chen12Huihui Bao13Tianlong Liu14National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaChinese Academy of Medical Science Research Unit, NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaChinese Academy of Medical Science Research Unit, NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaChinese Academy of Medical Science Research Unit, NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaYantai Animal Disease Control Center, Yantai 264003, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaYantai Agricultural Technology Extension Center, Yantai 264001, ChinaLivestock and Veterinary Development Center of Zoucheng, Hong Kong, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaChinese Academy of Medical Science Research Unit, NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaMicroplastics, defined as plastic fragments smaller than 5 mm, degrade from larger pollutants, with nanoscale microplastic particles presenting significant biological interactions. This study investigates the toxic effects of polystyrene nanoplastics (PS-NPs) on juvenile mice, which were exposed through lactation milk and drinking water at concentrations of 0.01 mg/mL, 0.1 mg/mL, and 1 mg/mL. The results show that PS-NP exposure during lactation and juvenile periods caused delayed weight gain and impaired organ development, particularly in the liver and kidneys, without causing functional abnormalities or toxic injuries. The primary toxicity of PS-NPs was observed in the intestinal tract, including shortened villi, disrupted tight junctions, inhibited epithelial cell proliferation, and oxidative stress responses. These findings highlight the importance of evaluating the developmental toxicity of nanoplastics at environmentally relevant doses.https://www.mdpi.com/2079-4991/15/1/69microplasticspolystyrene nanoplasticsdevelopmental miceintestinal toxicity |
| spellingShingle | Chaoyu Zhou Haiyan Wu Lei Zhang Xiao Xiao Xiaodan Wang Mingju Li Runqiu Cai Jia You Qi Chen Yifei Yang Xinyuan Tian Qianyu Bai Yinzhu Chen Huihui Bao Tianlong Liu Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice microplastics polystyrene nanoplastics developmental mice intestinal toxicity |
| title | Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice |
| title_full | Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice |
| title_fullStr | Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice |
| title_full_unstemmed | Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice |
| title_short | Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice |
| title_sort | intestinal barrier damage and growth retardation caused by exposure to polystyrene nanoplastics through lactation milk in developing mice |
| topic | microplastics polystyrene nanoplastics developmental mice intestinal toxicity |
| url | https://www.mdpi.com/2079-4991/15/1/69 |
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