Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals

• Published in: Anais Brasileiros de Dermatologia
• Main Authors: Luana Bernardes Arantes, Carmélia Santiago Reis, Alice Garbi Novaes, Marta Rodrigues de Carvalho, Leila Bernarda Donato Göttems, Maria Rita Carvalho Garbi Novaes
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Dermatologia 2017-10-01
• Subjects: Drug eruptions; Epidemiology; Stevens-Johnson syndrome
• Online Access: http://www.scielo.br/pdf/abd/v92n5/0365-0596-abd-92-05-0661.pdf

Abstract: Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Methods: Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. Limitations of the study: There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. Conclusion: There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions.