A DNA‐Modularized STING Agonist with Macrophage‐Selectivity and Programmability for Enhanced Anti‐Tumor Immunotherapy

Abstract The activation of cyclic GMP‐AMP (cGAMP) synthase (cGAS) and its adaptor, stimulator of interferon genes (STING), is known to reprogram the immunosuppressive tumor microenvironment for promoting antitumor immunity. To enhance the efficiency of cGAS‐STING pathway activation, macrophage‐selec...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Yingzhi Chen, Ruike Li, Qiao Duan, Lingling Wu, Xinyi Li, Aoxiang Luo, Yongming Zhang, Na Zhao, Kai Cui, Wenwei Wu, Tize Liu, Jian‐Bo Wan, Liufu Deng, Guiying Li, Lijun Hou, Weihong Tan, Zeyu Xiao
Format:	Article
Language:	English
Published:	Wiley 2024-08-01
Subjects:	aptamer cancer immunotherapy cGAS‐STING DNA nanotechnology drug delivery tumor‐associated macrophages
Online Access:	https://doi.org/10.1002/advs.202400149