Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies

• الحاوية / القاعدة: Biomedicines
• المؤلفون الرئيسيون: Min-Hee Yi, Jinkyung Lee, Subin Moon, EunA So, Geonhyeok Bang, Kyung-Sub Moon, Kyung-Hwa Lee
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: MDPI AG 2025-01-01
• الموضوعات: brain metastasis; glioblastoma; tumor-associated microglia; tumor-infiltrating T cells; tumor microenvironment
• الوصول للمادة أونلاين: https://www.mdpi.com/2227-9059/13/1/216

<b>Background</b>: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. Within this complex ecosystem, microglia and macrophages play fundamental roles, forming intricate networks with peripheral immune cell populations, particularly T cells. The precise mechanisms underlying microglial interactions with T cells and their contributions to immunosuppression remain incompletely understood. <b>Methods</b>: This review comprehensively examines the complex cellular dialogue between microglia and T cells in two prominent brain malignancies: primary glioblastoma and secondary brain metastases. <b>Results</b>: Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. <b>Conclusions</b>: Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention.