Genomic Characterization of Papillary Thyroid Cancer Reveals Germline Mutations Associated With Congenital Hypothyroidism

PURPOSEThyroid dyshormonogenesis, a form of congenital hypothyroidism, is characterized by defects in thyroid hormone synthesis genes, affecting both children and adults. However, the potential link between such genetic defects and the development of papillary thyroid cancer (PTC) remains unclear.ME...

Full description

Bibliographic Details
Published in:	JCO Global Oncology
Main Authors:	Vaishakhi Trivedi, Hitesh Kore, Disha Poojary, Vanita Noronha, Munita Bal, Pratik Chandrani, Anuradha Choughule, Priyanka Pange, Vinod Gupta, Nandini Menon, Vijay Patil, Minit Shah, Pankaj Chaturvedi, Kumar Prabhash, Amit Dutt
Format:	Article
Language:	English
Published:	American Society of Clinical Oncology 2025-05-01
Online Access:	https://ascopubs.org/doi/10.1200/GO-25-00043

Similar Items

Comprehensive Genomic Profiling of Anaplastic Thyroid Cancer Identifies Alterations in THRA, a Potential Modifier of Cellular Plasticity
by: Vaishakhi Trivedi, et al.
Published: (2025-07-01)

Association of Cutibacterium acnes with human thyroid cancer
by: Vaishakhi Trivedi, et al.
Published: (2023-11-01)

Identification of EGFR mutations in type II papillary renal cell carcinoma
by: Prerana Jha, et al.
Published: (2023-01-01)

Osimertinib for lung cancer cells harboring low-frequency EGFR T790M mutation
by: Asim Joshi, et al.
Published: (2022-08-01)

Impact of Molecular Tumor Board on the Clinical Management of Patients With Cancer
by: Vichitra Behel, et al.
Published: (2022-07-01)

NUT-midline carcinoma of the lung with rare BRD3-NUTM1 fusion
by: Prerana Jha, et al.
Published: (2024-01-01)

Assessment of plasma derived microbiome profiles in lung cancer using targeted and whole exome sequencing
by: Vichitra Behel, et al.
Published: (2025-06-01)

Authors' reply to Maskomani
by: Minit Shah, et al.
Published: (2023-01-01)

Erdafitinib for tumors with FGFR3 mutation: A promising targeted therapy
by: Jaspreet Kaur, et al.
Published: (2023-01-01)

NRAS mutation in differentiated thyroid cancer
by: Saswata Saha, et al.
Published: (2022-01-01)

The Impact of Baseline Vitamin D Level in Patients Receiving Gefitinib-Directed Therapy for EGFR-Mutant Non–Small-Cell Lung Cancer
by: Vanita Noronha, et al.
Published: (2024-05-01)

Molecular tumor board: Case 1-Interplay of EGFR, MET and PD-L1 in non-small cell lung carcinoma
by: Akhil Kapoor, et al.
Published: (2019-01-01)

Authors' reply to Batra et al., Chadha et al., and Deb et al.
by: Akhil Kapoor, et al.
Published: (2020-01-01)

Authors' reply to Dubey et al. and Bhattacharyya et al.
by: Akhil Kapoor, et al.
Published: (2020-01-01)

Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity.
by: Anuradha Chougule, et al.
Published: (2013-01-01)

Authors' reply to Krishnamurthy et al.
by: Goutam Santosh Panda, et al.
Published: (2022-01-01)

Cabozantinib: A narrative drug review
by: Vivek K Srigadha, et al.
Published: (2023-01-01)

Third-line therapy in the epidermal growth factor receptor mutation-positive advanced nonsmall-cell lung cancer
by: Vanita Noronha, et al.
Published: (2020-01-01)

Nutritional status and impact on outcomes of patients with locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: a pre-planned secondary analysis of a phase 3 randomized controlled trial
by: Vanita Noronha, et al.
Published: (2025-07-01)

Amivantamab: A narrative drug review
by: Anupa John, et al.
Published: (2023-01-01)

Authors' reply to Shah and Sahu
by: Anupa John, et al.
Published: (2023-01-01)

Real-World Experience of First-Line Osimertinib in EGFR Mutated Non-Small Cell Lung Cancers from a Tertiary Cancer Center, India
by: Atul Tiwari, et al.

Bendamustine in the third line or beyond in metastatic, recurrent, or relapsed head-and-neck cancers: A retrospective observational study
by: Vijay Patil, et al.
Published: (2022-01-01)

Authors' reply to Chandrasekharan et al. and Abbas
by: Akhil Kapoor, et al.
Published: (2020-01-01)

Paclitaxel with Mycidac-C in the second line and beyond in advanced head-and-neck cancer: A retrospective analysis from a tertiary cancer center
by: Rup J Sarma, et al.
Published: (2022-01-01)

Leptomeningeal metastasis from extracranial solid tumors
by: Dilip Harindran Vallathol, et al.
Published: (2020-01-01)

Authors' reply to Dhanushkodi et al. and Chalissery
by: Gunjesh Kumar Singh, et al.
Published: (2020-01-01)

Vaccination practices, efficacy, and safety in adults with cancer: A narrative review
by: Laboni Sarkar, et al.
Published: (2021-01-01)

Circulating tumor DNA profiling for non-invasive genomic analysis in Indian lung cancer patients: A real-world experience
by: Prerana Jha, et al.
Published: (2025-06-01)

Comprehensive Development and Implementation of Good Laboratory Practice for NGS Based Targeted Panel on Solid Tumor FFPE Tissues in Diagnostics
by: Anuradha Chougule, et al.
Published: (2022-05-01)

Weekly osimertinib dosing prevents EGFR mutant tumor cells destined to home mouse lungs
by: Ashwin Butle, et al.
Published: (2021-08-01)

Authors' reply to Nandi
by: Jaspreet Kaur, et al.
Published: (2023-01-01)

Genetic counselling in India: The state of affairs
by: Minit Shah, et al.
Published: (2023-01-01)

Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
by: Poonam Joshi, et al.
Published: (2015-01-01)

The masquerader
by: Abhishek Mahajan, et al.
Published: (2022-01-01)

Real-World Experience of Patients with Inoperable, Stage III Non-small-Cell Lung Cancer Treated with Durvalumab after Chemoradiotherapy: Indian Experience
by: Vanita Noronha, et al.
Published: (2020-07-01)

Translation and Validation of COST - FACIT (Version 2) Questionnaire into Hindi and Marathi to Assess Financial Toxicity in Indian Cancer Patients
by: Amit Joshi, et al.
Published: (2022-04-01)

Palliative oral triple metronomic chemotherapy in a patient with head-and-neck cancer during the COVID-19 pandemic in India: A case report
by: Sachin Babanrao Dhumal, et al.
Published: (2020-01-01)

Understanding the Impact of Population and Cancer Type on Tumor Mutation Burden Scores: A Comprehensive Whole-Exome Study in Cancer Patients From India
by: Nishtha AjitSingh Tanwar, et al.
Published: (2023-09-01)

Immunoglobulin G4-related disease (IgG4-RD) manifestations in the head-and-neck: A narrative review with a focus on imaging
by: Shreya Shukla, et al.
Published: (2023-01-01)