New Metabolic Influencer on Oxytocin Release: The Ghrelin
Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytoci...
| 發表在: | Molecules |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
MDPI AG
2019-02-01
|
| 主題: | |
| 在線閱讀: | https://www.mdpi.com/1420-3049/24/4/735 |
| _version_ | 1852721444416389120 |
|---|---|
| author | Renáta Szabó Rudolf Ménesi Andor H. Molnár Zita Szalai Lejla Daruka Gábor Tóth János Gardi Márta Gálfi Denise Börzsei Krisztina Kupai Anna Juhász Marianna Radács Ferenc A. László Csaba Varga Anikó Pósa |
| author_facet | Renáta Szabó Rudolf Ménesi Andor H. Molnár Zita Szalai Lejla Daruka Gábor Tóth János Gardi Márta Gálfi Denise Börzsei Krisztina Kupai Anna Juhász Marianna Radács Ferenc A. László Csaba Varga Anikó Pósa |
| author_sort | Renáta Szabó |
| collection | DOAJ |
| container_title | Molecules |
| description | Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [<span style="font-variant: small-caps;">d</span>-Lys<sup>3</sup>]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [<span style="font-variant: small-caps;">d</span>-Lys<sup>3</sup>]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options. |
| format | Article |
| id | doaj-art-3bb8751cc97a42979cf34bfa00f6fa3f |
| institution | Directory of Open Access Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-3bb8751cc97a42979cf34bfa00f6fa3f2025-08-19T21:12:21ZengMDPI AGMolecules1420-30492019-02-0124473510.3390/molecules24040735molecules24040735New Metabolic Influencer on Oxytocin Release: The GhrelinRenáta Szabó0Rudolf Ménesi1Andor H. Molnár2Zita Szalai3Lejla Daruka4Gábor Tóth5János Gardi6Márta Gálfi7Denise Börzsei8Krisztina Kupai9Anna Juhász10Marianna Radács11Ferenc A. László12Csaba Varga13Anikó Pósa14Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryInstitute of Physical Education and Sport Sciences, Gyula Juhász Faculty of Education, University of Szeged, 6725 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Medical Chemistry, Faculty of Medicine, University of Szeged, 6720 Szeged, HungaryFirst Department of Internal Medicine, Faculty of Medicine, University of Szeged, 6720 Szeged, HungaryDepartment of Environmental Biology and Education, Gyula Juhász Faculty of Education, Institute of Applied Science, University of Szeged, 6725 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Psychiatry, Faculty of Medicine, University of Szeged, 6725 Szeged, HungaryDepartment of Environmental Biology and Education, Gyula Juhász Faculty of Education, Institute of Applied Science, University of Szeged, 6725 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, HungaryBackground: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [<span style="font-variant: small-caps;">d</span>-Lys<sup>3</sup>]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [<span style="font-variant: small-caps;">d</span>-Lys<sup>3</sup>]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.https://www.mdpi.com/1420-3049/24/4/735ghrelinghrelin antagonistoxytocinneuropeptide regulation |
| spellingShingle | Renáta Szabó Rudolf Ménesi Andor H. Molnár Zita Szalai Lejla Daruka Gábor Tóth János Gardi Márta Gálfi Denise Börzsei Krisztina Kupai Anna Juhász Marianna Radács Ferenc A. László Csaba Varga Anikó Pósa New Metabolic Influencer on Oxytocin Release: The Ghrelin ghrelin ghrelin antagonist oxytocin neuropeptide regulation |
| title | New Metabolic Influencer on Oxytocin Release: The Ghrelin |
| title_full | New Metabolic Influencer on Oxytocin Release: The Ghrelin |
| title_fullStr | New Metabolic Influencer on Oxytocin Release: The Ghrelin |
| title_full_unstemmed | New Metabolic Influencer on Oxytocin Release: The Ghrelin |
| title_short | New Metabolic Influencer on Oxytocin Release: The Ghrelin |
| title_sort | new metabolic influencer on oxytocin release the ghrelin |
| topic | ghrelin ghrelin antagonist oxytocin neuropeptide regulation |
| url | https://www.mdpi.com/1420-3049/24/4/735 |
| work_keys_str_mv | AT renataszabo newmetabolicinfluenceronoxytocinreleasetheghrelin AT rudolfmenesi newmetabolicinfluenceronoxytocinreleasetheghrelin AT andorhmolnar newmetabolicinfluenceronoxytocinreleasetheghrelin AT zitaszalai newmetabolicinfluenceronoxytocinreleasetheghrelin AT lejladaruka newmetabolicinfluenceronoxytocinreleasetheghrelin AT gabortoth newmetabolicinfluenceronoxytocinreleasetheghrelin AT janosgardi newmetabolicinfluenceronoxytocinreleasetheghrelin AT martagalfi newmetabolicinfluenceronoxytocinreleasetheghrelin AT deniseborzsei newmetabolicinfluenceronoxytocinreleasetheghrelin AT krisztinakupai newmetabolicinfluenceronoxytocinreleasetheghrelin AT annajuhasz newmetabolicinfluenceronoxytocinreleasetheghrelin AT mariannaradacs newmetabolicinfluenceronoxytocinreleasetheghrelin AT ferencalaszlo newmetabolicinfluenceronoxytocinreleasetheghrelin AT csabavarga newmetabolicinfluenceronoxytocinreleasetheghrelin AT anikoposa newmetabolicinfluenceronoxytocinreleasetheghrelin |