Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exp...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Pharmaceutics
المؤلفون الرئيسيون: Elena Hipper, Michaela Blech, Dariush Hinderberger, Patrick Garidel, Wolfgang Kaiser
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2021-12-01
الموضوعات:
photo-degradation
analytical methods
post-translational modification
protein degradation
reactive oxygen species
الوصول للمادة أونلاين:https://www.mdpi.com/1999-4923/14/1/72
الوصف
الملخص:UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques.
تدمد:1999-4923

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