Structural diversity and biological activities of naturally derived bafilomycins from actinomycetes

Abstract Background Bafilomycins (Baf) are plecomacrolide antibiotics characterized by a 16-membered macrocyclic lactone containing two sets of conjugated dienes linked by a 1,3-dimethyl propan-2-ol (C3) spacer to an unusually folded tetrahydropyran ring. Bafs are known for their vacuolar H+-adenosi...

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Bibliographic Details
Published in:	Beni-Suef University Journal of Basic and Applied Sciences
Main Authors:	Aileen Bayot Custodio, John Edward Ico Zapater, Edwin Plata Alcantara
Format:	Article
Language:	English
Published:	SpringerOpen 2025-04-01
Subjects:	Bafilomycins Structural diversity Plecomacrolide antibiotics Actinomycetes V-ATPase inhibitors
Online Access:	https://doi.org/10.1186/s43088-025-00622-0

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