CAPS and Munc13: CATCHRs that SNARE vesicles

• 出版年: Frontiers in Endocrinology
• 主要な著者: Declan J James, Thomas F J Martin
• フォーマット: 論文
• 言語: 英語
• 出版事項: Frontiers Media S.A. 2013-12-01
• 主題: Vesicle fusion; SNAREs; Munc13; Keywords: CAPS (aka CADPS); priming factors; vesicle priming
• オンライン･アクセス: http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00187/full
• ISSN: 1664-2392

Abstract. CAPS (Calcium-dependent Activator Protein for Secretion, aka CADPS) and Munc13 (Mammalian Unc-13) proteins function to prime vesicles for Ca2+-triggered exocytosis in neurons and neuroendocrine cells. CAPS and Munc13 proteins contain conserved C-terminal domains that promote the assembly of SNARE complexes for vesicle priming. Similarities of the C-terminal domains of CAPS/Munc13 proteins with CATCHR (Complex Associated with Tethering Containing Helical Rods) domains in multi-subunit tethering complexes have been reported. Multi-subunit tethering complexes coordinate multiple interactions for SNARE complex assembly at constitutive membrane fusion steps. We review aspects of these diverse tethering and priming factors to identify common operating principles.