Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice

The G2019S mutation in the leucine-rich repeat kinase 2 (<i>LRRK2</i>) gene is associated with late-onset Parkinson’s disease (PD). Although PD affects men and women differently, longitudinal studies examining sex- and age-dependent alterations in mice carrying the G2019S mutation are li...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Ning Yao, Olga Skiteva, Karima Chergui
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	BAC: bacterial artificial chromosome DA: dopaminergic DAT: dopamine transporter KI: knock-in LRRK2: leucine-rich repeat kinase 2 PD: Parkinson’s disease
Online Access:	https://www.mdpi.com/2218-273X/13/1/51