Sickle cell anemia: An update on diagnosis, management and prevention strategies
Sickle cell anemia is the most common disease entity of all the monogenic disorders. This is an autosomal recessive disorder. HbS polymerization, vaso-occlusion, and hemolytic anemia are central to the pathophysiology of sickle cell disease, they precipitate a cascade of pathologic events, which in...
| Published in: | Indian Journal of Community and Family Medicine |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
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| Subjects: | |
| Online Access: | http://www.ijcfm.org/article.asp?issn=2395-2113;year=2018;volume=4;issue=2;spage=67;epage=71;aulast=Mishra |
| Summary: | Sickle cell anemia is the most common disease entity of all the monogenic disorders. This is an autosomal recessive disorder. HbS polymerization, vaso-occlusion, and hemolytic anemia are central to the pathophysiology of sickle cell disease, they precipitate a cascade of pathologic events, which in turn lead to a wide range of complications. The disease is particularly more prevalent in certain regions of the country like Odisha, Madhya Pradesh, Tamilnadu and has a significant impact on morbidity. Community based approach by providing availability of screening tests, & pre-marital and pre-pregnancy counselling should be initiated to reduce the disease burden in the society. |
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| ISSN: | 2395-2113 |