| الملخص: | Sarcopenia and sarcopenic obesity are conditions that are underdiagnosed in medical practice. Given their significant impact on quality of life with advancing age, identifying these disorders and their underlying causes, as well as developing targeted intervention strategies, are major areas of interest in current medical research. Investigating single nucleotide polymorphisms (SNPs) associated with these conditions, particularly in patients admitted to rehabilitation units, may open new avenues for diagnosis, prevention and treatment. This study conducts a rigorous review of the literature to evaluate the relationship between polymorphisms, sarcopenia and sarcopenic obesity, while also examining how the response to rehabilitation treatment may vary. Three polymorphisms were studied as having a significant influence on sarcopenia and sarcopenic obesity through their involvement in specific functional pathways. Among these, one polymorphism has been extensively studied in relation to medical rehabilitation, with notable associations observed between genotype and treatment response. Implementing screening for sarcopenia and sarcopenic obesity, along with genetic polymorphism analysis, represents a promising research direction. The findings of this preliminary study make a meaningful contribution to the current medical literature and may support the development of personalized rehabilitation interventions for affected patients.
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