The role of HIV-1 Gag and genomic RNA interactions in virion assembly
The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise...
| Published in: | Frontiers in Microbiology |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642090/full |
| _version_ | 1849433380494508032 |
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| author | Takaaki Koma Takaaki Koma Bao Quoc Le Khanh Quoc Tran Naoya Doi Tomoyuki Kondo Kei Miyakawa Akio Adachi Masako Nomaguchi Masako Nomaguchi |
| author_facet | Takaaki Koma Takaaki Koma Bao Quoc Le Khanh Quoc Tran Naoya Doi Tomoyuki Kondo Kei Miyakawa Akio Adachi Masako Nomaguchi Masako Nomaguchi |
| author_sort | Takaaki Koma |
| collection | DOAJ |
| container_title | Frontiers in Microbiology |
| description | The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process. This article provides an updated overview and perspective on HIV-1 virion assembly, with a particular focus on the role of Gag-RNA interactions. |
| format | Article |
| id | doaj-art-3f271724be3a4e2b8980a8d2eaac2bfc |
| institution | Directory of Open Access Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-3f271724be3a4e2b8980a8d2eaac2bfc2025-08-20T03:37:02ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.16420901642090The role of HIV-1 Gag and genomic RNA interactions in virion assemblyTakaaki Koma0Takaaki Koma1Bao Quoc Le2Khanh Quoc Tran3Naoya Doi4Tomoyuki Kondo5Kei Miyakawa6Akio Adachi7Masako Nomaguchi8Masako Nomaguchi9Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanDivision of Interdisciplinary Researches for Medicine and Photonics, Institute of Post–LED Photonics, Tokushima University, Tokushima, JapanDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanAIDS Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, JapanDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, JapanDivision of Interdisciplinary Researches for Medicine and Photonics, Institute of Post–LED Photonics, Tokushima University, Tokushima, JapanThe virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process. This article provides an updated overview and perspective on HIV-1 virion assembly, with a particular focus on the role of Gag-RNA interactions.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642090/fullHIV-1virion assemblyGagRNAmembraneGag oligomerization |
| spellingShingle | Takaaki Koma Takaaki Koma Bao Quoc Le Khanh Quoc Tran Naoya Doi Tomoyuki Kondo Kei Miyakawa Akio Adachi Masako Nomaguchi Masako Nomaguchi The role of HIV-1 Gag and genomic RNA interactions in virion assembly HIV-1 virion assembly Gag RNA membrane Gag oligomerization |
| title | The role of HIV-1 Gag and genomic RNA interactions in virion assembly |
| title_full | The role of HIV-1 Gag and genomic RNA interactions in virion assembly |
| title_fullStr | The role of HIV-1 Gag and genomic RNA interactions in virion assembly |
| title_full_unstemmed | The role of HIV-1 Gag and genomic RNA interactions in virion assembly |
| title_short | The role of HIV-1 Gag and genomic RNA interactions in virion assembly |
| title_sort | role of hiv 1 gag and genomic rna interactions in virion assembly |
| topic | HIV-1 virion assembly Gag RNA membrane Gag oligomerization |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642090/full |
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