The role of HIV-1 Gag and genomic RNA interactions in virion assembly

The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise...

Full description

Bibliographic Details
Published in:	Frontiers in Microbiology
Main Authors:	Takaaki Koma, Bao Quoc Le, Khanh Quoc Tran, Naoya Doi, Tomoyuki Kondo, Kei Miyakawa, Akio Adachi, Masako Nomaguchi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	HIV-1 virion assembly Gag RNA membrane Gag oligomerization
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642090/full

Similar Items

Positive correlation between structural disorder of the HIV-1 Gag N-terminal segment and progeny virus particle formation
by: Takaaki Koma, et al.
Published: (2025-10-01)

Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package
by: Yi-Ru Lin, et al.
Published: (2022-04-01)

HIV-1 Mutant Assembly, Processing and Infectivity Expresses Pol Independent of Gag
by: Fu-Hsien Yu, et al.
Published: (2020-01-01)

Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity
by: William E. Diehl, et al.
Published: (2021-06-01)

An Overview about New Methods in Management of Gag Reflex during Dental Treatment: A Systematic Review
by: Mohammad Mehdizadeh, et al.
Published: (2023-12-01)

Gag Problem in Dental Treatment Assessment and Methods to Control it.
by: Karama MT Al – Nuaimy
Published: (2010-08-01)

Awareness and prevention of patient gag reflex among pedodontists in India: A web-based survey
by: Soumik Roy, et al.
Published: (2016-01-01)

Evaluation of the effects of acupuncture on P6 and anti-gagging acupoints on the gag reflex
by: Abbas Haghighat, et al.
Published: (2015-01-01)

Distinct Contributions of Different Domains within the HIV-1 Gag Polyprotein to Specific and Nonspecific Interactions with RNA
by: Tomas Kroupa, et al.
Published: (2020-04-01)

A Reliable and Valid Survey to Predict a Patient’s Gagging Intensity
by: Casey M. Hearing, et al.
Published: (2014-07-01)

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity
by: Kazuaki Monde, et al.
Published: (2017-04-01)

FRET-Based Detection and Quantification of HIV-1 Virion Maturation
by: Anamaria D. Sarca, et al.
Published: (2021-03-01)

Role of Gag and lipids during HIV-1 assembly in CD4 T cells and Macrophages
by: Charlotte eMariani, et al.
Published: (2014-06-01)

Comparative evaluation of effect of microcurrent electrical stimulation on acupoints to control gag reflex in patients receiving prosthodontic treatment: An in vivo study
by: Shanvi Agrawal, et al.
Published: (2022-01-01)

Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation
by: Na Qu, et al.
Published: (2017-09-01)

How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain
by: Jéromine Klingler, et al.
Published: (2020-08-01)

A virus-like particle assembly system for probing the HIV-1 Gag–Pol dimerization domain: supporting evidence for reverse transcriptase involvement in protease activation by influencing Gag–Pol/Gag–Pol interaction
by: Shih-Han Hsieh, et al.
Published: (2025-04-01)

Gag Reflex Reduction in A Patient with Maxillofacial Prosthesis. ( A Clinical Report )
by: Nadira A Hatim, et al.
Published: (2008-04-01)

Biomarkers of Glycosaminoglycans (GAG) accumulation in patients with mucopolysaccharidosis type VI—LeukoGAG, Corneal Opacification (COM) and Carotid Intima Media Thickening (CIMT)
by: Young Bae Sohn, et al.
Published: (2024-03-01)

Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions
by: Sikao Guo, et al.
Published: (2023-07-01)

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging
by: Zetao Cheng, et al.
Published: (2025-04-01)

Commentary: Origin and evolution of pathogenic coronaviruses
by: Shun Adachi, et al.
Published: (2020-04-01)

The 3rd anniversary of Frontiers in Virology: aiming to consolidate the virus research
by: Akio Adachi, et al.
Published: (2024-10-01)

Editorial: HIV/SIV basic research update
by: Akio Adachi, et al.
Published: (2023-08-01)

Addition of sub-anaesthetic dose of ketamine reduces gag reflex during propofol based sedation for upper gastrointestinal endoscopy: A prospective randomised double-blind study
by: Manish Tandon, et al.
Published: (2014-01-01)

Retroviral integration site selection: a running Gag?
by: Paul Lesbats, et al.
Published: (2018-11-01)

Evaluation of the effect of Elaeagnus angustifolia drug film on gag reflex
by: Ehsan Hekmatian, et al.
Published: (2011-01-01)

S v P – The Abuse of Protection Orders to "Gag" Victims of Rape
by: Sheena Swemmer
Published: (2023-06-01)

Visualization of Retroviral Gag-Genomic RNA Cellular Interactions Leading to Genome Encapsidation and Viral Assembly: An Overview
by: Serena Bernacchi
Published: (2022-02-01)

Acupuncture for Relief of Gag Reflex in Patients Undergoing Transoesophageal Echocardiography—A Protocol for a Randomized Placebo-Controlled Trial
by: Taras I. Usichenko, et al.
Published: (2020-03-01)

Specific Interaction of DARPin with HIV-1 CA<sub>NTD</sub> Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane
by: Sutpirat Moonmuang, et al.
Published: (2022-04-01)

The Conserved Tyr176/Leu177 Motif in the α-Helix 9 of the Feline Immunodeficiency Virus Capsid Protein Is Critical for Gag Particle Assembly
by: César A. Ovejero, et al.
Published: (2019-09-01)

Relationship between HIV-1 Gag Multimerization and Membrane Binding
by: Christopher Sumner, et al.
Published: (2022-03-01)

A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation
by: Nicholas S. Groves, et al.
Published: (2025-05-01)

Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag
by: Meng Qu, et al.
Published: (2020-06-01)

Evaluation of the Effect of Benzydamine Hydrochloride on the Intensity of Gag Reflex: A Randomized Single-Blind Clinical Trial
by: Mohammad Mehdi Torabi, et al.
Published: (2024-06-01)

Creative Story through 9GAG Application in Teaching Speaking
by: Muhamad Sofian Hadi, et al.
Published: (2021-04-01)

Intranasal Midazolam May Prevent Gagging Reflex: a Case Report
by: Meral Arslan Malkoc, et al.
Published: (2013-10-01)

Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE
by: Boeras Ioana, et al.
Published: (2012-01-01)

The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation
by: R. Elliot Murphy, et al.
Published: (2020-05-01)