Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

Extensive transcriptional alterations are observed in cancer, many of which activate core biological processes established in unicellular organisms or suppress differentiation pathways formed in metazoans. Through rigorous, integrative analysis of genomics data from a range of solid tumors, we show...

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Bibliographic Details
Published in:	eLife
Main Authors:	Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-02-01
Subjects:	cancer evolution networks orthology mutations multicellularity
Online Access:	https://elifesciences.org/articles/40947

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