Effects of oral administration of 5 immunosuppressive agents on activated T‐cell cytokine expression in healthy dogs

Abstract Background Dogs are often adminstered >1 immunosuppressive medication when treating immune‐mediated diseases, and determining whether these different medications affect IL‐2 expression would be useful when performing pharmacodynamic monitoring during cyclosporine therapy. Hypothesis/Obje...

Full description

Bibliographic Details
Published in:	Journal of Veterinary Internal Medicine
Main Authors:	Todd M. Archer, Charlee Mulligan, Lakshmi Narayanan, Caitlin Riggs, Claire Fellman, John M. Thomason, Robert W. Wills, Dawn M. Boothe, Crisanta Cruz‐Espindola, Roy Harmon, Andrew J. Mackin
Format:	Article
Language:	English
Published:	Wiley 2020-05-01
Subjects:	azathioprine cyclosporine interferon gamma interleukin 2 leflunomide mycophenolate mofetil
Online Access:	https://doi.org/10.1111/jvim.15729

Similar Items

Sensing Methods of Immunosuppressant Drugs: Calcineurin Inhibitors and Purine Synthesis Inhibitor Agents
by: Zahra Golsanamlou, et al.
Published: (2021-12-01)

Retrospective analysis of immunosuppressive and anti‐thrombotic protocols in nonassociative immune mediated hemolytic anemia in dogs
by: Jennifer Weng, et al.
Published: (2023-03-01)

Granulomatosis with polyangiitis – therapeutic challenge
by: Dorota Szydlarska, et al.
Published: (2016-02-01)

A Case of Repeat Kidney Transplant Intolerant to Multiple First-line Immunosuppressive Agents Mycophenolate Mofetil, Azathioprine, and Calcineurin Inhibitors
by: Puneet Arora, et al.
Published: (2024-12-01)

The medical treatment for autoimmune hepatitis through corticosteroid to new immunosuppressive agents: A concise review
by: Roger D. Soloway, et al.
Published: (2007-10-01)

Mycophenolate mofetil versus azathioprine as a first-line treatment for autoimmune hepatitis: a comparative systematic review and meta-analysis
by: Amani M. Ali, et al.
Published: (2025-08-01)

Mycophenolate mofetil as an alternative treatment for autoimmune hepatitis
by: Seung Woon Park, et al.
Published: (2016-06-01)

The efficacy of immunosuppressive drugs induction therapy for lupus nephritis: a systematic review and network meta-analysis
by: Yongqiang Dong, et al.
Published: (2023-12-01)

Short story of antirheumatic therapy.VIII. The immunodepressants
by: P. Marson, et al.
Published: (2012-03-01)

Incidence of serious infections in patients with ANCA-associated vasculitis receiving immunosuppressive therapy: A systematic review and meta-analysis
by: Athanasios Vassilopoulos, et al.
Published: (2023-03-01)

Long-term results of mycophenolate mofetil vs. azathioprine use in individuals with autoimmune hepatitis
by: George N. Dalekos, et al.
Published: (2022-12-01)

Current and emerging treatment options in the management of lupus
by: Jordan N, et al.
Published: (2016-03-01)

Recovery of T‐cell function in healthy dogs following cessation of oral cyclosporine administration
by: Lakshmi Narayanan, et al.
Published: (2020-08-01)

Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review
by: Siva Hamdani, et al.
Published: (2025-06-01)

A Comparison of Azathioprine and Mycophenolate Mofetil as Adjuvant Drugs in Patients with Pemphigus: A Retrospective Cohort Study
by: Siriorn Sukanjanapong, et al.
Published: (2019-12-01)

Alternative treatment regimens in autoimmune hepatitis: how justified is their choice?
by: M. V. Matsievich, et al.
Published: (2018-11-01)

Survival of Adjuvant Drugs for Treatment of Pemphigus: A Population-based Cohort Study
by: Khalaf Kridin, et al.
Published: (2021-09-01)

Effectiveness of myocarditis therapy depending on the diagnosis approach (with or without myocardial biopsy)
by: O. V. Blagova, et al.
Published: (2021-05-01)

Determining Effectiveness of “Off-Label Therapies” for Multiple Sclerosis in a Real-World Setting
by: Lekha Pandit, et al.
Published: (2024-06-01)

Effectiveness and tolerability of systemic therapies in oral lichen planus: A retrospective cohort study
by: Emma L. Myers, BA, et al.
Published: (2024-06-01)

Safety and Efficacy of Pemphigus Treatments: A Subtype-Specific Review of Conventional and Emerging Therapies
by: Pokphazz Christjaroon, et al.
Published: (2025-09-01)

In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others
by: Junjun Mao, et al.
Published: (2024-08-01)

Regression of Post-transplant <i>Kaposi′s sarcoma</i> after Replacing Cyclosporine with Mycophenolate Mofetil
by: Hussein Magdi, et al.
Published: (2001-01-01)

Treatment of chronic non-infectious uveitis and scleritis
by: Daniele C. Rossi, et al.
Published: (2019-03-01)

Mycophenolate mofetil as second line treatment in autoimmune hepatitis – A retrospective single center analysis
by: Mirjam Kolev, et al.
Published: (2022-01-01)

Trends in the treatment of idiopathic nephrotic syndrome in children based on a single-centre experience
by: Monika Augustynowicz, et al.
Published: (2018-06-01)

Multitarget therapy for pembrolizumab-induced refractory hemophagocytic lympho histiocytosis
by: Hiroshi Kobe, et al.
Published: (2021-12-01)

Clinical experience with mycophenolate mofetil in systemic autoimmune conditions refractory to common immunosuppressive therapies
by: C Bandelier
Published: (2009-01-01)

Indications and Long-Term Outcomes of Using Mycophenolate Mofetil Monotherapy in Substitution for Calcineurin Inhibitors in Liver Transplantation
by: Carlos Jiménez-Romero, et al.
Published: (2025-02-01)

ACVIM consensus statement on the treatment of immune‐mediated hemolytic anemia in dogs
by: James W. Swann, et al.
Published: (2019-05-01)

Therapeutic effects of topical Mycophenolate mofetil on hydroquinone-induced depigmentation in Guinea pigs and mice
by: Yuan Guo, et al.
Published: (2025-12-01)

Does mycophenolate mofetil increase the risk of cytomegalovirus infection in solid organ transplant recipients?: A mini-review
by: Alice Tung Wan Song, et al.

Comparative efficacy and safety of mycophenolate mofetil and azathioprine in combination with corticosteroids in the treatment of lymphocytic myocarditis
by: R. S. Rud, et al.
Published: (2021-12-01)

Intersticial pulmonary disease in patients with systemic sclerosis. Narrative review of the literature
by: Álvarez-Barreneche, María Fernanda, et al.
Published: (2017-07-01)

Cross-sectional analysis of immunosuppressive regimens focused on everolimus after liver transplantation in a Korean high-volume transplantation center
by: Sang-Hyun Kang, et al.
Published: (2019-12-01)

Mycophenolic acid trough level assessment in patients with lupus nephritis; does it make a difference?
by: Ahmed E. Abdulgalil, et al.
Published: (2025-03-01)

Place of immunosuppressants in chronic inflammatory bowel diseases.
by: Frida CHETTAB
Published: (2024-12-01)

De novo Renal Transplantation after Kaposi Sarcoma: Favorable Outcome in a Patient Receiving Sirolimus and Mycophenolate-Based Immunosuppression
by: F. Friedersdorff, et al.
Published: (2010-04-01)

Complete and sustained resolution of calcinosis universalis in a juvenile dermatomyositis case with mycophenolate mofetil
by: Mustafa Çakan, et al.
Published: (2019-10-01)

Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies
by: Corrado Campochiaro, et al.
Published: (2024-04-01)