Alkylative Aziridine Ring-Opening Reactions
In this study, the highly strained three-membered aziridine ring was successfully activated as the aziridinium ion by alkylation of the ring nitrogen with a methyl, ethyl or allyl group, which was followed by ring opening with external nucleophiles such as acetate and azide. Such alkylative aziridin...
| 發表在: | Molecules |
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| Main Authors: | , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
MDPI AG
2021-03-01
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| 主題: | |
| 在線閱讀: | https://www.mdpi.com/1420-3049/26/6/1703 |
| 總結: | In this study, the highly strained three-membered aziridine ring was successfully activated as the aziridinium ion by alkylation of the ring nitrogen with a methyl, ethyl or allyl group, which was followed by ring opening with external nucleophiles such as acetate and azide. Such alkylative aziridine ring opening provides an easy route for the synthesis of various <i>N</i>-alkylated amine-containing molecules with concomitant introduction of an external nucleophile at either its α- or β-position. |
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| ISSN: | 1420-3049 |