Progress of ursolic acid on the regulation of macrophage: summary and prospect
Ursolic acid (UA), a prevalent pentacyclic triterpenoid found in numerous fruits and herbs, has garnered significant attention for its vital role in anti-inflammatory processes and immune regulation. The study of immune cells has consistently been a focal point, particularly regarding macrophages, w...
| Published in: | Frontiers in Immunology |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576771/full |
| _version_ | 1849406208845283328 |
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| author | Wenjing Feng Kehong Yang Ying Zou Zhaohua Xiao Rongkang Qian Ronghua Qian |
| author_facet | Wenjing Feng Kehong Yang Ying Zou Zhaohua Xiao Rongkang Qian Ronghua Qian |
| author_sort | Wenjing Feng |
| collection | DOAJ |
| container_title | Frontiers in Immunology |
| description | Ursolic acid (UA), a prevalent pentacyclic triterpenoid found in numerous fruits and herbs, has garnered significant attention for its vital role in anti-inflammatory processes and immune regulation. The study of immune cells has consistently been a focal point, particularly regarding macrophages, which play crucial roles in antigen presentation, immunomodulation, the inflammatory response, and pathogen phagocytosis. This paper reveals the underlying regulatory effects of UA on the function of macrophages and the specific therapeutic effects of UA on a variety of diseases. Owing to the superior effect of UA on macrophages, different types of macrophages in different tissues have been described. Through the multifaceted regulation of macrophage function, UA may provide new ideas for the development of novel anti-inflammatory and immunomodulatory drugs. However, to facilitate its translation into actual medical means, the specific mechanism of UA in macrophages and its clinical application still need to be further studied. |
| format | Article |
| id | doaj-art-40ff30e06d67409da182cbeade23c898 |
| institution | Directory of Open Access Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-40ff30e06d67409da182cbeade23c8982025-08-20T03:53:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15767711576771Progress of ursolic acid on the regulation of macrophage: summary and prospectWenjing Feng0Kehong Yang1Ying Zou2Zhaohua Xiao3Rongkang Qian4Ronghua Qian5Key Laboratory of Vascular Biology and Translational Medicine of Hunan Province, Medical School, Hunan University of Chinese Medicine, Changsha, ChinaKey Laboratory of Vascular Biology and Translational Medicine of Hunan Province, Medical School, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Anatomy, Anatomy Teaching Center of Hunan University of Chinese Medicine, Changsha, ChinaXiangya Hospital, Central South University, Changsha, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Qian Rongkang Clinic, Loudi, ChinaKey Laboratory of Vascular Biology and Translational Medicine of Hunan Province, Medical School, Hunan University of Chinese Medicine, Changsha, ChinaUrsolic acid (UA), a prevalent pentacyclic triterpenoid found in numerous fruits and herbs, has garnered significant attention for its vital role in anti-inflammatory processes and immune regulation. The study of immune cells has consistently been a focal point, particularly regarding macrophages, which play crucial roles in antigen presentation, immunomodulation, the inflammatory response, and pathogen phagocytosis. This paper reveals the underlying regulatory effects of UA on the function of macrophages and the specific therapeutic effects of UA on a variety of diseases. Owing to the superior effect of UA on macrophages, different types of macrophages in different tissues have been described. Through the multifaceted regulation of macrophage function, UA may provide new ideas for the development of novel anti-inflammatory and immunomodulatory drugs. However, to facilitate its translation into actual medical means, the specific mechanism of UA in macrophages and its clinical application still need to be further studied.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576771/fullursolic acidmacrophageimmunoregulationinflammationcytokine |
| spellingShingle | Wenjing Feng Kehong Yang Ying Zou Zhaohua Xiao Rongkang Qian Ronghua Qian Progress of ursolic acid on the regulation of macrophage: summary and prospect ursolic acid macrophage immunoregulation inflammation cytokine |
| title | Progress of ursolic acid on the regulation of macrophage: summary and prospect |
| title_full | Progress of ursolic acid on the regulation of macrophage: summary and prospect |
| title_fullStr | Progress of ursolic acid on the regulation of macrophage: summary and prospect |
| title_full_unstemmed | Progress of ursolic acid on the regulation of macrophage: summary and prospect |
| title_short | Progress of ursolic acid on the regulation of macrophage: summary and prospect |
| title_sort | progress of ursolic acid on the regulation of macrophage summary and prospect |
| topic | ursolic acid macrophage immunoregulation inflammation cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576771/full |
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