Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 stimulated blood
Background: Accurate diagnosis of latent tuberculosis infected (LTBI) individuals is important in identifying individuals at risk of developing active tuberculosis. Current diagnosis of LTBI routinely relies on the detection and measurement of immune responses using the Tuberculin Skin Test (TST) an...
| Published in: | Frontiers in Molecular Medicine |
|---|---|
| Main Authors: | Antony M. Rapulana, Thabo Mpotje, Omolara O. Baiyegunhi, Hlumani Ndlovu, Theresa K. Smit, Timothy D. McHugh, Mohlopheni J. Marakalala |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmmed.2024.1345510/full |
Similar Items
HBHA induces IL-10 from CD4+ T cells in patients with active tuberculosis but IFN-γ and IL-17 from individuals with Mycobacterium tuberculosis infection
by: Mai Izumida, et al.
Published: (2024-08-01)
by: Mai Izumida, et al.
Published: (2024-08-01)
Effect of ESAT-6 on Phagocytosis Activity, ROS, NO, IFN-γ, and IL-10 in Peripheral Blood Mononuclear Cells of Pulmonary Tuberculosis Patients
by: Dicky Santosa, et al.
Published: (2022-08-01)
by: Dicky Santosa, et al.
Published: (2022-08-01)
Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients
by: Pryscilla Fanini Wowk, et al.
Published: (2017-05-01)
by: Pryscilla Fanini Wowk, et al.
Published: (2017-05-01)
Immunobiological Methods for Monitoring Latent Tuberculosis Infection in Children and Adolescents and Analysis of Tuberculosis Infection Reactivation
by: M. A. Vladimirskiy, et al.
Published: (2024-12-01)
by: M. A. Vladimirskiy, et al.
Published: (2024-12-01)
ESAT-6-ELISpot and interferon γ in the diagnosis of pleural tuberculosis
by: Waheed Shouman, et al.
Published: (2012-07-01)
by: Waheed Shouman, et al.
Published: (2012-07-01)
Alternative biomarkers of tuberculosis infection in patients with immune-mediated inflammatory diseases
by: Elisa Petruccioli, et al.
Published: (2023-11-01)
by: Elisa Petruccioli, et al.
Published: (2023-11-01)
Signaling C-type lectin receptors in antimycobacterial immunity.
by: Mohlopheni J Marakalala, et al.
Published: (2017-06-01)
by: Mohlopheni J Marakalala, et al.
Published: (2017-06-01)
Prevalence and Risk Factors of Latent Tuberculosis Infection (LTBI) at Madura Boarding School as a High-Risk Congregate Setting
by: Muhammad Arif Ananto, et al.
Published: (2024-08-01)
by: Muhammad Arif Ananto, et al.
Published: (2024-08-01)
ELISPOT Refinement Using Spot Morphology for Assessing Host Responses to Tuberculosis
by: Sally A. Sharpe, et al.
Published: (2012-03-01)
by: Sally A. Sharpe, et al.
Published: (2012-03-01)
Enhanced IFN-γ, but not IL-2, response to Mycobacterium tuberculosis antigens in HIV/latent TB co-infected patients on long-term HAART
by: Girmay Desalegn, et al.
Published: (2019-10-01)
by: Girmay Desalegn, et al.
Published: (2019-10-01)
Study Of Detection Of Serum CXCL10 In Vitiligo Patients
by: Abd-El Aziz El- Rifaie, et al.
Published: (2022-01-01)
by: Abd-El Aziz El- Rifaie, et al.
Published: (2022-01-01)
Mycobacterial FtsEX-RipC interaction is required for normal growth and cell morphology in rifampicin and low ionic strength conditions
by: Veneshley Samuels, et al.
Published: (2024-03-01)
by: Veneshley Samuels, et al.
Published: (2024-03-01)
In vitro Analysis for Macrophage Binding and Pro-inflammatory Responses to Candida albicans
by: Mohlopheni Marakalala
Published: (2014-05-01)
by: Mohlopheni Marakalala
Published: (2014-05-01)
Investigation the level of IL-10 and IFN-γ in mice infected with Entamoeba histolytica and treated with earthworm powder
by: Nebrass Faleh Chachain, et al.
Published: (2019-08-01)
by: Nebrass Faleh Chachain, et al.
Published: (2019-08-01)
Latent Tuberculosis Patients Have an Increased Frequency of IFN-γ-Producing CD5+ B Cells, Which Respond Efficiently to Mycobacterial Proteins
by: Julio Flores-Gonzalez, et al.
Published: (2023-06-01)
by: Julio Flores-Gonzalez, et al.
Published: (2023-06-01)
Potential Role of CXCL10 in Monitoring Response to Treatment in Leprosy Patients
by: Helen Ferreira, et al.
Published: (2021-07-01)
by: Helen Ferreira, et al.
Published: (2021-07-01)
Generation of Multicellular 3D Liver Organoids From Induced Pluripotent Stem Cells as a Tool for Modelling Liver Diseases
by: Setjie Maepa, et al.
Published: (2024-08-01)
by: Setjie Maepa, et al.
Published: (2024-08-01)
Screening for Latent Tuberculosis Infection in People Living with HIV: TUBHIVIT Project, a Multicenter Italian Study
by: Luca Pipitò, et al.
Published: (2024-05-01)
by: Luca Pipitò, et al.
Published: (2024-05-01)
Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation
by: Neha Gupta, et al.
Published: (2023-05-01)
by: Neha Gupta, et al.
Published: (2023-05-01)
Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection
by: Mudathir Abdelshafea Abdelkareem Abakar, et al.
Published: (2023-07-01)
by: Mudathir Abdelshafea Abdelkareem Abakar, et al.
Published: (2023-07-01)
Serum levels of cytokines (TNF-α, IFN-γ& IL-10) in Type-2 diabetic patients with HCV infection
by: May Y. Saour, et al.
Published: (2011-07-01)
by: May Y. Saour, et al.
Published: (2011-07-01)
Antiviral immune response against HTLV-1 invalidates T-SPOT.TB® results in patients with HTLV-1-positive rheumatic diseases
by: Masatoshi Kimura, et al.
Published: (2024-10-01)
by: Masatoshi Kimura, et al.
Published: (2024-10-01)
Systemic IL-10 and IFN-γ Levels in Respiratory Syncytial Virus- and Rhinovirus-Infected Bulgarian Children with Acute Bronchiolitis and Their Impact on Clinical Manifestation
by: Emiliya Kostadinova, et al.
Published: (2025-04-01)
by: Emiliya Kostadinova, et al.
Published: (2025-04-01)
Diagnostic accuracy of the ESAT6-CFP10 skin test for latent tuberculosis infection among jail detainees
by: Xinru Fei, et al.
Published: (2025-10-01)
by: Xinru Fei, et al.
Published: (2025-10-01)
The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
by: Sandra Barroso-Arévalo, et al.
Published: (2021-06-01)
by: Sandra Barroso-Arévalo, et al.
Published: (2021-06-01)
Elevated NS1 serum levels reduce CD119 expression and CXCL-10 synthesis in patients with dengue hemorrhagic fever
by: Fernanda Gonçalves Garcia, et al.
Published: (2024-07-01)
by: Fernanda Gonçalves Garcia, et al.
Published: (2024-07-01)
Diagnostic value of tuberculosis-specific antigens ESAT-6 and CFP10 in lymph node tuberculosis
by: Xueqian Chen, et al.
Published: (2024-04-01)
by: Xueqian Chen, et al.
Published: (2024-04-01)
Successful treatment of life-threatening mycobacteriosis using adjunctive gamma-interferon therapy with genetic analysis
by: P. Confalonieri, et al.
Published: (2024-01-01)
by: P. Confalonieri, et al.
Published: (2024-01-01)
Decreasing Bone Resorption by Inducing Anti-Osteoclastogenic IFN-γ and IL-10 Expression in the Spleen Through an Electromagnetic Field on LPS-Induced Osteoporosis Mice
by: Myeong-Hyun Nam, et al.
Published: (2025-08-01)
by: Myeong-Hyun Nam, et al.
Published: (2025-08-01)
Cytokines Profile in Newly Diagnosed Children with Type 1 Diabetes Mellitus
by: Eman M. Saleh
Published: (2009-10-01)
by: Eman M. Saleh
Published: (2009-10-01)
CFP10: mFcγ2 as a novel tuberculosis vaccine candidate increases immune response in mouse
by: Ali Asghar Baghani, et al.
Published: (2017-02-01)
by: Ali Asghar Baghani, et al.
Published: (2017-02-01)
Comparison of interferon gamma release assay and tuberculin skin test for diagnosis of latent tuberculosis in psoriasis patients planned for systemic therapy
by: Shekhar Neema, et al.
Published: (2022-01-01)
by: Shekhar Neema, et al.
Published: (2022-01-01)
Differential Early Secreted Antigen Target (ESAT) 6 kDa–induced IFN-γ and SOCS1 expression distinguishes latent and active tuberculosis
by: Kiran Iqbal Masood, et al.
Published: (2014-01-01)
by: Kiran Iqbal Masood, et al.
Published: (2014-01-01)
Editorial: Factors for the progression from latent tuberculosis infection to tuberculosis disease
by: Cheng Chen, et al.
Published: (2023-06-01)
by: Cheng Chen, et al.
Published: (2023-06-01)
Tuberculosis and Risk of Emphysema among US Adults in the NHANES I Epidemiologic Follow-Up Study Cohort, 1971–1992
by: Anita Joshi, et al.
Published: (2023-12-01)
by: Anita Joshi, et al.
Published: (2023-12-01)
Strategies to reach and motivate migrant communities at high risk for TB to participate in a latent tuberculosis infection screening program: a community-engaged, mixed methods study among Eritreans
by: Ineke Spruijt, et al.
Published: (2020-03-01)
by: Ineke Spruijt, et al.
Published: (2020-03-01)
Genotyped cluster investigations versus standard contact tracing: comparative impact on latent tuberculosis infection cascade of care in a low-incidence region
by: Michael Asare-Baah, et al.
Published: (2025-01-01)
by: Michael Asare-Baah, et al.
Published: (2025-01-01)
Characterization of QuantiFERON-TB-Plus Results in Patients with Tuberculosis Infection and Multiple Sclerosis
by: Elisa Petruccioli, et al.
Published: (2025-08-01)
by: Elisa Petruccioli, et al.
Published: (2025-08-01)
QuantiFERON® TB Gold IT in the diagnosis of active pulmonary TB
by: Clara Fabris, et al.
Published: (2010-03-01)
by: Clara Fabris, et al.
Published: (2010-03-01)
Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis
by: Mohlopheni J. Marakalala, et al.
Published: (2018-05-01)
by: Mohlopheni J. Marakalala, et al.
Published: (2018-05-01)
Similar Items
-
HBHA induces IL-10 from CD4+ T cells in patients with active tuberculosis but IFN-γ and IL-17 from individuals with Mycobacterium tuberculosis infection
by: Mai Izumida, et al.
Published: (2024-08-01) -
Effect of ESAT-6 on Phagocytosis Activity, ROS, NO, IFN-γ, and IL-10 in Peripheral Blood Mononuclear Cells of Pulmonary Tuberculosis Patients
by: Dicky Santosa, et al.
Published: (2022-08-01) -
Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients
by: Pryscilla Fanini Wowk, et al.
Published: (2017-05-01) -
Immunobiological Methods for Monitoring Latent Tuberculosis Infection in Children and Adolescents and Analysis of Tuberculosis Infection Reactivation
by: M. A. Vladimirskiy, et al.
Published: (2024-12-01) -
ESAT-6-ELISpot and interferon γ in the diagnosis of pleural tuberculosis
by: Waheed Shouman, et al.
Published: (2012-07-01)
