Diagnostic and metabolic insights into secondary lactose intolerance in infants via fecal lactose quantification and gut microbiome profiling

BackgroundSecondary Lactose intolerance (SLI) is common among infants in China, primarily resulting from secondary lactase deficiency due to mucosal damage. Current diagnostic methods are limited by poor sensitivity and specificity.ObjectiveTo investigate gut microbial composition and metabolic dysf...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jian Kuang, Mengmei Zhang, Xiangyu Bian, Xin Wang, Xiaoqiong Li, Qingbin Wu, Jinjun Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-04-01
Subjects:	secondary lactose intolerance gut microbiota lactose glycolysis metabolism SCFAs 16s rRNA in vitro fermentation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1711945/full