Discussion on the calculation formula of haemoglobin glycation index for Chinese population

• Published in: Scientific Reports
• Main Authors: Li Gao, Bing Wang, Xiaohong Yang, Mingyang Xu, Qian Wu, Hua Liu
• Format: Article
• Language: English
• Published: Nature Portfolio 2024-11-01
• Subjects: Haemoglobin glycation index; HbA1c; CHARLS; Diabetes
• Online Access: https://doi.org/10.1038/s41598-024-80015-y

Abstract To explore the formula for calculating the haemoglobin glycation index (HGI) in an appropriate Chinese population. Evaluating the applicability of the HGI calculation formula proposed by Hempe et al. in the Chinese population; according to the data from CHARLS 2011, 10,587 self-reported nondiabetics aged 20 years and older were selected as the study subjects, regression equations were constructed to fit the linear relationship between HbA1c and FPG in the population, and the profile characteristics of the resultant population were analysed. The standardized HGI formula put forth by Hempe and colleagues has been found unsuitable for application to the Chinese population. Leveraging CHARLS dataset, we derive a novel HGI calculation formula tailored to the Chinese demographic: HGI = Measured HbA1c-Predicted HbA1c, where Predicted HbA1c = 0.011×FPG + 4.032. We found statistically significant differences in HGI among obese individuals; those with higher waist circumference, total cholesterol levels, LDL levels, diastolic blood pressure and those with lower HDL levels. The HGI calculation formula proposed using CHARLS data is more applicable to the Chinese population and can be used as a standardised HGI to Chinese.