Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

Abstract What is the relationship between enzymes and metabolites, the two major constituents of metabolic networks? We propose three alternative relationships between enzyme capacity and metabolite concentration alterations based on a Michaelis–Menten kinetic; that is enzyme capacities, metabolite...

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Bibliographic Details
Published in:	Molecular Systems Biology
Main Authors:	Sarah‐Maria Fendt, Joerg Martin Buescher, Florian Rudroff, Paola Picotti, Nicola Zamboni, Uwe Sauer
Format:	Article
Language:	English
Published:	Springer Nature 2010-04-01
Subjects:	design principle metabolic network metabolomics proteomics transcriptome
Online Access:	https://doi.org/10.1038/msb.2010.11

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