Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series
Abstract Biliary stent placement is widely used in clinical, especially in patients with pancreatic cancer complicated with obstructive jaundice. Pyogenic liver abscess (PLA) is a severe complication following biliary stent placement which predominantly occurs in the right lobe of the liver, with an...
| 發表在: | BMC Cancer |
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| Main Authors: | , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
BMC
2025-05-01
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| 主題: | |
| 在線閱讀: | https://doi.org/10.1186/s12885-025-14377-5 |
| 總結: | Abstract Biliary stent placement is widely used in clinical, especially in patients with pancreatic cancer complicated with obstructive jaundice. Pyogenic liver abscess (PLA) is a severe complication following biliary stent placement which predominantly occurs in the right lobe of the liver, with an incidence rate ranging from 4.3% to 13.5% and a mortality rate up to 30%. It is related to the following mechanisms: retrograde bacterial infection; bile stasis and increased bile duct pH; stent-related bile duct injury; biofilm formation; immune system suppression. The main causative pathogens are gram-negative bacilli, particularly Escherichia coli and Klebsiella pneumoniae. The combination of antibiotic therapy and percutaneous transhepatic abscess drainage is the main treatment option. |
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| ISSN: | 1471-2407 |