Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series
Abstract Biliary stent placement is widely used in clinical, especially in patients with pancreatic cancer complicated with obstructive jaundice. Pyogenic liver abscess (PLA) is a severe complication following biliary stent placement which predominantly occurs in the right lobe of the liver, with an...
| 發表在: | BMC Cancer |
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| Main Authors: | , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
BMC
2025-05-01
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| 主題: | |
| 在線閱讀: | https://doi.org/10.1186/s12885-025-14377-5 |
| _version_ | 1849705239522836480 |
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| author | Dongxue Geng Nan Lv Yi Miao |
| author_facet | Dongxue Geng Nan Lv Yi Miao |
| author_sort | Dongxue Geng |
| collection | DOAJ |
| container_title | BMC Cancer |
| description | Abstract Biliary stent placement is widely used in clinical, especially in patients with pancreatic cancer complicated with obstructive jaundice. Pyogenic liver abscess (PLA) is a severe complication following biliary stent placement which predominantly occurs in the right lobe of the liver, with an incidence rate ranging from 4.3% to 13.5% and a mortality rate up to 30%. It is related to the following mechanisms: retrograde bacterial infection; bile stasis and increased bile duct pH; stent-related bile duct injury; biofilm formation; immune system suppression. The main causative pathogens are gram-negative bacilli, particularly Escherichia coli and Klebsiella pneumoniae. The combination of antibiotic therapy and percutaneous transhepatic abscess drainage is the main treatment option. |
| format | Article |
| id | doaj-art-443771cddaac4cbbb8fef27e6db97ff4 |
| institution | Directory of Open Access Journals |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| spelling | doaj-art-443771cddaac4cbbb8fef27e6db97ff42025-08-20T02:00:14ZengBMCBMC Cancer1471-24072025-05-012511610.1186/s12885-025-14377-5Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case seriesDongxue Geng0Nan Lv1Yi Miao2Department of Pancreas Center, The Affiliated BenQ Hospital of Nanjing Medical UniversityDepartment of Pancreas Center, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Pancreas Center, The Affiliated BenQ Hospital of Nanjing Medical UniversityAbstract Biliary stent placement is widely used in clinical, especially in patients with pancreatic cancer complicated with obstructive jaundice. Pyogenic liver abscess (PLA) is a severe complication following biliary stent placement which predominantly occurs in the right lobe of the liver, with an incidence rate ranging from 4.3% to 13.5% and a mortality rate up to 30%. It is related to the following mechanisms: retrograde bacterial infection; bile stasis and increased bile duct pH; stent-related bile duct injury; biofilm formation; immune system suppression. The main causative pathogens are gram-negative bacilli, particularly Escherichia coli and Klebsiella pneumoniae. The combination of antibiotic therapy and percutaneous transhepatic abscess drainage is the main treatment option.https://doi.org/10.1186/s12885-025-14377-5Pyogenic liver abscessBiliary stentPancreatic cancer |
| spellingShingle | Dongxue Geng Nan Lv Yi Miao Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series Pyogenic liver abscess Biliary stent Pancreatic cancer |
| title | Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series |
| title_full | Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series |
| title_fullStr | Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series |
| title_full_unstemmed | Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series |
| title_short | Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series |
| title_sort | pyogenic liver abscess following biliary stent placement in pancreatic cancer patients a retrospective case series |
| topic | Pyogenic liver abscess Biliary stent Pancreatic cancer |
| url | https://doi.org/10.1186/s12885-025-14377-5 |
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